Targeting SHP2 as a therapeutic strategy for inflammatory diseases

被引：29
作者：
Liu, Yang [1 ]
Yang, Xiaohe [1 ]
Wang, Yali [1 ]
Yang, Yueying [1 ]
Sun, Dejuan [1 ]
Li, Hua [1 ,2 ]
Chen, Lixia [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 214卷
基金：
中国国家自然科学基金;
关键词：
SHP2; inhibitors; Inflammation; Cancer; TYROSINE-PHOSPHATASE SHP2; SMALL HETERODIMER PARTNER; HELICOBACTER-PYLORI; HEMATOPOIETIC STEM; FEEDBACK-REGULATION; INSULIN-RESISTANCE; CANCER-CELLS; INHIBITION; ACTIVATION; RECEPTOR;
D O I：
10.1016/j.ejmech.2021.113264
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
With the change of lifestyle and the acceleration of aging process, inflammatory diseases have increasingly become one of the most vital threats to global human health. SHP2 protein is a non-receptor tyrosine phosphatase encoded by PTPN11 gene, and it is widely expressed in various tissues and cells. Numerous studies have shown that SHP2 plays important roles in the regulation of inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases and metabolic diseases. In this paper, the roles of SHP2 in inflammatory diseases of various physiological systems were reviewed. At the same time, the latest SHP2 inhibitors were summarized, which will hold a promise for the therapeutic potential in future. (C) 2021 Elsevier Masson SAS. All rights reserved.
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页数：16
相关论文
共 156 条
[131]   Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression [J].
Wang, Yao-Chen ;
Wu, De-Wei ;
Wu, Tzu-Chin ;
Wang, Lee ;
Chen, Chih-Yi ;
Lee, Huei .
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 14 (01) :47-56
[132]   Helicobacter pylori Infection Activates Src Homology-2 Domain-Containing Phosphatase 2 To Suppress IFN-γ Signaling [J].
Wang, Yu-Chih ;
Chen, Chia-Ling ;
Sheu, Bor-Shyang ;
Yang, Yao-Jong ;
Tseng, Po-Chun ;
Hsieh, Chia-Yuan ;
Lin, Chiou-Feng .
JOURNAL OF IMMUNOLOGY, 2014, 193 (08) :4149-4158
[133]   MUTATION OF THE INSULIN-RECEPTOR AT TYROSINE-960 INHIBITS SIGNAL TRANSMISSION BUT DOES NOT AFFECT ITS TYROSINE KINASE-ACTIVITY [J].
WHITE, MF ;
LIVINGSTON, JN ;
BACKER, JM ;
LAURIS, V ;
DULL, TJ ;
ULLRICH, A ;
KAHN, CR .
CELL, 1988, 54 (05) :641-649
[134]   Insulin signaling in health and disease [J].
White, MF .
SCIENCE, 2003, 302 (5651) :1710-1711
[135]   Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases [J].
Woo, Joo Hong ;
Lee, Jee Hoon ;
Kim, Hyunmi ;
Park, Soo Jung ;
Joe, Eun-hye ;
Jou, Ilo .
EXPERIMENTAL NEUROBIOLOGY, 2015, 24 (02) :95-102
[136]   TNFSF9 Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Pancreatic Cancer [J].
Wu, Jiao ;
Wang, Yunpeng ;
Jiang, Zheng .
JOURNAL OF GASTROINTESTINAL CANCER, 2021, 52 (01) :150-159
[137]   Fibrotic disease and the TH1/TH2 paradigm [J].
Wynn, TA .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (08) :583-594
[138]   Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2 [J].
Xia, L-x ;
Hua, W. ;
Jin, Y. ;
Tian, B-p ;
Qiu, Z-w ;
Zhang, C. ;
Che, L-q ;
Zhou, H-b ;
Wu, Y-f ;
Huang, H-q ;
Lan, F. ;
Ke, Y-h ;
Lee, J. J. ;
Li, W. ;
Ying, S-m ;
Chen, Z-h ;
Shen, H-h .
CELL DEATH & DISEASE, 2016, 7 :e2175-e2175
[139]   Heteroatom-Substituted Analogues of Orphan Nuclear Receptor Small Heterodimer Partner Ligand and Apoptosis Inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic Acid [J].
Xia, Zebin ;
Farhana, Lulu ;
Correa, Ricardo G. ;
Das, Jayanta K. ;
Castro, David J. ;
Yu, Jinghua ;
Oshima, Robert G. ;
Reed, John C. ;
Fontana, Joseph A. ;
Dawson, Marcia I. .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (11) :3793-3816
[140]   Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS-induced colitis [J].
Xiao, Junhua ;
Zhang, Gufang ;
Gao, Sujun ;
Shen, Jiaqing ;
Feng, Huang ;
He, Zhilong ;
Xu, Chunfang .
MOLECULAR MEDICINE REPORTS, 2020, 22 (03) :2235-2244
78910111213141516