Targeting SHP2 as a therapeutic strategy for inflammatory diseases

被引：28

作者：

Liu, Yang ^{[1
]}

Yang, Xiaohe ^{[1
]}

Wang, Yali ^{[1
]}

Yang, Yueying ^{[1
]}

Sun, Dejuan ^{[1
]}

Li, Hua ^{[1
,2
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 214卷

基金：

中国国家自然科学基金;

关键词：

SHP2; inhibitors; Inflammation; Cancer; TYROSINE-PHOSPHATASE SHP2; SMALL HETERODIMER PARTNER; HELICOBACTER-PYLORI; HEMATOPOIETIC STEM; FEEDBACK-REGULATION; INSULIN-RESISTANCE; CANCER-CELLS; INHIBITION; ACTIVATION; RECEPTOR;

D O I：

10.1016/j.ejmech.2021.113264

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With the change of lifestyle and the acceleration of aging process, inflammatory diseases have increasingly become one of the most vital threats to global human health. SHP2 protein is a non-receptor tyrosine phosphatase encoded by PTPN11 gene, and it is widely expressed in various tissues and cells. Numerous studies have shown that SHP2 plays important roles in the regulation of inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases and metabolic diseases. In this paper, the roles of SHP2 in inflammatory diseases of various physiological systems were reviewed. At the same time, the latest SHP2 inhibitors were summarized, which will hold a promise for the therapeutic potential in future. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：16

共 156 条

[1] Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop [J].

Aceto, Nicola ;

Sausgruber, Nina ;

Brinkhaus, Heike ;

Gaidatzis, Dimos ;

Martiny-Baron, Georg ;

Mazzarol, Giovanni ;

Confalonieri, Stefano ;

Quarto, Micaela ;

Hu, Guang ;

Balwierz, Piotr J. ;

Pachkov, Mikhail ;

Elledge, Stephen J. ;

van Nimwegen, Erik ;

Stadler, Michael B. ;

Bentires-Alj, Mohamed .

NATURE MEDICINE, 2012, 18 (04) :529-537

[2] SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors [J].

Ahmed, Tamer A. ;

Adamopoulos, Christos ;

Karoulia, Zoi ;

Wu, Xuewei ;

Sachidanandam, Ravi ;

Aaronson, Stuart A. ;

Poulikakos, Poulikos I. .

CELL REPORTS, 2019, 26 (01) :65-+

[3] Helicobacter pylori persistence:: An overview of interactions between H-pylori and host immune defenses [J].

Algood, Holly M. Scott ;

Cover, Timothy L. .

CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (04) :597-+

[4] The interaction of host genetic factors and Helicobacter pylori infection [J].

Ando T. ;

Goto Y. ;

Ishiguro K. ;

Maeda O. ;

Watanabe O. ;

Ohmiya N. ;

Niwa Y. ;

Hamajima N. ;

El-Omar E. ;

Goto H. .

Inflammopharmacology, 2007, 15 (1) :10-14

[5] CXCL8 protects human neurons from amyloid-β-induced neurotoxicity: Relevance to Alzheimer's disease [J].

Ashutosh ;

Kou, Wei ;

Cotter, Robin ;

Borgmann, Kathleen ;

Wu, Li ;

Persidsky, Raisa ;

Sakhuja, Namita ;

Ghorpade, Anuja .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 412 (04) :565-571

[6] Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment [J].

Axelrad, Jordan E. ;

Lichtiger, Simon ;

Yajnik, Vijay .

WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (20) :4794-4801

[7] Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors [J].

Bagdanoff, Jeffrey T. ;

Chen, Zhouliang ;

Acker, Michael ;

Chen, Ying-Nan ;

Chan, Homan ;

Dore, Michael ;

Firestone, Brant ;

Fodor, Michelle ;

Fortanet, Jorge ;

Hentemann, Murphy ;

Kato, Mitsunori ;

Koenig, Robert ;

LaBonte, Laura R. ;

Liu, Shumei ;

Mohseni, Movarid ;

Ntaganda, Rukundo ;

Sarver, Patrick ;

Smith, Troy ;

Sendzik, Martin ;

Stams, Travis ;

Spence, Stan ;

Towler, Christopher ;

Wang, Hongyun ;

Wang, Ping ;

Williams, Sarah L. ;

LaMarche, Matthew J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (04) :1781-1792

[8] Macrophages in intestinal homeostasis and inflammation [J].

Bain, Calum C. ;

Mowat, Allan McI .

IMMUNOLOGICAL REVIEWS, 2014, 260 (01) :102-117

[9] Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes [J].

Balasubramanian, A ;

Ganju, RK ;

Groopman, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (37) :35755-35766

[10] An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ [J].

Banks, Alexander S. ;

McAllister, Fiona E. ;

Camporez, Joao Paulo G. ;

Zushin, Peter-James H. ;

Jurczak, Michael J. ;

Laznik-Bogoslavski, Dina ;

Shulman, Gerald I. ;

Gygi, Steven P. ;

Spiegelman, Bruce M. .

NATURE, 2015, 517 (7534) :391-U581

← 1 2 3 4 5 6 7 8 9 10 →