Armadillo and dTCF: a marriage made in the nucleus

被引：77
作者：
Cavallo, R
Rubenstein, D
Peifer, M
机构：
[1] UNIV N CAROLINA,CURRICULUM GENET & MOL BIOL,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599
[3] UNIV N CAROLINA,DEPT DERMATOL,CHAPEL HILL,NC 27599
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 04期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0959-437X(97)80071-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.
引用
收藏
页码：459 / 466
页数：8
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