Armadillo and dTCF: a marriage made in the nucleus

被引：77

作者：

Cavallo, R

Rubenstein, D

Peifer, M

机构：

[1] UNIV N CAROLINA,CURRICULUM GENET & MOL BIOL,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599

[3] UNIV N CAROLINA,DEPT DERMATOL,CHAPEL HILL,NC 27599

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-437X(97)80071-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.

引用

页码：459 / 466

页数：8

共 69 条

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