The Relationship between Serum Total Bilirubin and Carotid Intima-Media Thickness in Patients with Prehypertension

被引:1
作者
Lyu, Qing-shan [1 ]
Huang, Yu-qing [2 ]
机构
[1] Cent Hosp Yongzhou, Dept Cardiol, Yongzhou, Hunan, Peoples R China
[2] Hypertens Res Lab Guangdong, Cardiovasc Inst, 96 Dongchuan Rd, Guangzhou 510100, Guangdong, Peoples R China
关键词
total bilirubin; prehypertension; subclinical atherosclerosis; carotid intima-media thickness; C-REACTIVE PROTEIN; ATHEROSCLEROSIS; MARKER; MEN;
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Aim. It has been found that serum total bilirubin has a vital role in anti-inflammatory and antioxidant progress. Prehypertension, the intermediate stage between normal blood pressure and hypertension, is linked with subclinical atherosclerosis and target-organ damage. Methods. This study was designed to evaluate the relationship between total bilirubin and carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, in patients with prehypertension. Results. We consecutively enrolled 219 patients with prehypertension. All the participants were divided into two groups according to cIMT values (<0.9 vs. >= 0.9 mm). We found that the increased cIMT group has higher systolic blood pressure, triglyceride and C-reactive protein, but lower total bilirubin compared to the normal cIMT group. The cIMT was negatively correlated with total bilirubin. Multivariate regression analyses revealed total bilirubin was an independent factor for subclinical atherosclerosis. Conclusion. This study demonstrated that serum total bilirubin was inversely related with cIMT, and was an independent predictor of subclinical atherosclerosis in patients with prehypertension.
引用
收藏
页码:757 / 763
页数:7
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