Hormonal replacement therapy in adolescents and young women with chemo- or radio-induced premature ovarian insufficiency: Practical recommendations

被引：27

作者：

Cattoni, A. ^{[1
]}

Parissone, F. ^{[2
]}

Porcari, I. ^{[2
]}

Molinari, S. ^{[1
]}

Masera, N. ^{[1
]}

Franchi, M. ^{[2
]}

Cesaro, S. ^{[3
]}

Gaudino, R. ^{[4
]}

Passoni, P. ^{[5
]}

Balduzzi, A. ^{[1
]}

机构：

[1] Univ Milano Bicocca, Fdn Monza & Brianza Bambino & Mamma, Azienda Osped San Gerardo, Dept Pediat, Via Pergolesi 33, I-20900 Monza, Italy

[2] Univ Verona, Azienda Osped Univ Integrata Verona, Dept Obstet & Gynecol, Piazzale Aristide Stefani 1, I-37126 Verona, Italy

[3] Univ Verona, Azienda Osped Univ Integrata Verona, Dept Mother & Child, Pediat Hematol Oncol, Piazzale Aristide Stefani 1, I-37126 Verona, Italy

[4] Univ Verona, Azienda Osped Univ Integrata Verona, Pediat Endocrinol, Piazzale Aristide Stefani 1, I-37126 Verona, Italy

[5] Azienda Osped San Gerardo, Dept Obstet & Gynecol, Via Pergolesi 33, I-20900 Monza, Italy

来源：

BLOOD REVIEWS | 2021年 / 45卷

关键词：

Hormone replacement therapy; Iatrogenic premature ovarian insufficiency; Childhood cancer survivors; Hematopoietic stem cell transplantation; Bone mineral density; Puberty induction; BONE-MARROW-TRANSPLANTATION; COMBINED ORAL-CONTRACEPTIVES; LONG-TERM SURVIVORS; SEX STEROID REPLACEMENT; TOTAL-BODY IRRADIATION; CHILDHOOD-CANCER; TURNER-SYNDROME; VENOUS THROMBOEMBOLISM; TRANSDERMAL ESTRADIOL; CONDITIONING REGIMENS;

D O I：

10.1016/j.blre.2020.100730

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In women with premature ovarian insufficiency (POI), hormonal therapy (HT) is indicated to decrease the risk of morbidity and to treat symptoms related to prolonged hypoestrogenism. While general recommendations for the management of HT in adults with POI have been published, no systematic suggestions focused on girls, adolescents and young women with POI following gonadotoxic treatments (chemotherapy, radiotherapy, stem cell transplantation) administered for pediatric cancer are available. In order to highlight the challenging issues specifically involving this cohort of patients and to provide clinicians with the proposal of practical therapeutic protocol, we revised the available literature in the light of the shared experience of a multidisciplinary team of pediatric oncologists, gynecologists and endocrinologists. We hereby present the proposals of a practical scheme to induce puberty in prepubertal girls and a decisional algorithm that should guide the clinician in approaching HT in post-pubertal adolescents and young women with iatrogenic POI.

引用

页数：10

共 88 条

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ACOG, 2018, OBSTET GYNECOL, V132, pe67

[2] Nocturnal application of transdermal estradiol patches produces levels of estradiol that mimic those seen at the onset of spontaneous puberty in girls [J].