Bioactive caffeic acid esters from Glycyrrhiza glabra

被引：19

作者：

Dey, Surajit ^{[1
]}

Deepak, Mundkinajeddu ^{[1
]}

Setty, Manjunath ^{[2
]}

D'Souza, Prashanth ^{[1
]}

Agarwal, Amit ^{[1
]}

Sangli, Gopal Krishna ^{[1
]}

机构：

[1] Nat Remedies Pvt Ltd, R&D Ctr, Bangalore, Karnataka, India

[2] Manipal Coll Pharmaceut Sci, Dept Pharmacognosy, Manipal, Karnataka, India

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 18期

关键词：

ABTS; antioxidant; docosyl caffeate; DPPH; eicosanyl caffeate; elastase; Glycyrrhiza glabra; ANTIOXIDANT CONSTITUENTS; ANTINEPHRITIS; FORMULATION; OXIDATION; ANTIULCER; LICORICE; LDL;

D O I：

10.1080/14786410802134348

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC50 values of 0.99 mu g mL(-1) and 1.4 mu g mL(-1) for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays. The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra.

引用

页码：1657 / 1663

页数：7

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