Comparison of one-year costs of Type 2 diabetes treatment with insulin glargine or insulin detemir in a basal supported oral therapy (BOT) in Germany

被引:0
作者
Pscherer, S. [3 ]
Dietrich, E. S. [1 ]
Dippel, F. -W. [2 ]
Neilson, A. R. [1 ]
机构
[1] HealthEcon AG, CH-4001 Basel, Switzerland
[2] Sanofi Aventis Deutschland GmbH, Berlin, Germany
[3] Klinikum Traunstein, Traunstein, Germany
关键词
Basal insulin; insulin glargine; insulin detemir; Type; 2; diabetes; cost analysis; 52-WEEK;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: A one-year cost analysis comparing basal insulin analogues glargine (IG Lantus(R)) versus detemir (ID, Levemir(R)) in combination with oral antidiabetic drugs (basal supported oral therapy; BOT) in insulin naive Type 2 diabetes patients in Germany based on the results of a randomized controlled clinical trial (RCT). The trial demonstrated equivalent treatment efficacy. Materials and methods: Total direct diabetes treatment costs were estimated from the perspective of the German statutory health insurance (SHI) for the time horizon of one-year. Simulated resources included medication (insulin, oral antidiabetic drugs) and consumable items (needles, blood glucose test strips and lancets). Initial and final insulin doses per kg body weight and proportion of patients with once/twice daily insulin injection were taken from the above mentioned RCT. Unit costs were taken from official German price lists and sources. Deterministic-(DTA) and probabilistic sensitivity analyses (PSA) oil resource use and unit costs were performed to test robustness of the results. Results: Average annual treatment costs per patient (base case) were (sic) 849 for glargine and (sic) 1,334 for detemir resulting in cost savings of (sic) 486 per patient per year (36%). Costs of insulins were (sic) 469 (IG) and (sic) 746 (ID). Costs of consumable items amounted at (sic) 380 (IG) and (sic) 588 (ID) respectively. Sensitivity analyses confirmed the findings in favor of insulin glargine. PSA results found cost savings ranging from (sic) 429 to (sic) 608 (5th/95th percentiles). Conclusions: The current model estimated that insulin glargine was associated with lower annual treatment costs of (sic) 486 (36%) compared to the use of insulin detemir while the same glycemic control is expected to be achieved.
引用
收藏
页码:129 / 137
页数:9
相关论文
共 24 条
[21]  
SCHULENBURG JMV, 2007, GESUNDH OKON QUAL MA, V12, P285
[22]  
SWINNEN S, 2009, DIABETES RES CLIN PR, V84, P24
[23]  
TETLOW AP, 2008, 44 M EUR ASS DIAB RO
[24]  
ROPER W EUROPE DIABE