Microwave-assisted synthesis of substituted imidazoles on a solid support under solvent-free conditions

被引：227
作者：
Usyatinsky, AY [1 ]
Khmelnitsky, YL [1 ]
机构：
[1] Albany Mol Res Inc, EnzyMed Div, Iowa City, IA 52242 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 26期
关键词：
microwave chemistry; solvent-free synthesis; substituted imidazoles; combinatorial synthesis;
D O I：
10.1016/S0040-4039(00)00771-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The solvent-free microwave-assisted synthesis of 2,4,5-substituted and 1,2,4,5-substituted imidazoles is reported. Imidazoles are obtained as a result of the condensation of a 1,2-dicarbonyl compound with an aldehyde and an amine using acidic alumina impregnated with ammonium acetate as the solid support. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5031 / 5034
页数：4
相关论文
共 11 条
  • [1] Benzimidazoles: Oxidative heterocyclization via nitrobenzene and dimethylsufloxide on silica submitted to microwave or ultraviolet irradiation
    Ben-Alloum, A
    Bakkas, S
    Soufiaoui, M
    [J]. TETRAHEDRON LETTERS, 1998, 39 (25) : 4481 - 4484
  • [2] Remarkable fast n-alkylation of azaheterocycles under microwave irradiation in dry media
    Bogdal, D
    Pielichowski, J
    Jaskot, K
    [J]. HETEROCYCLES, 1997, 45 (04) : 715 - 722
  • [3] NOVEL SYNTHESIS OF ARYLIMIDAZOLES USING MICROWAVE IRRADIATION IN DRY MEDIUM
    BOUGRIN, K
    SOUFIAOUI, M
    [J]. TETRAHEDRON LETTERS, 1995, 36 (21) : 3683 - 3686
  • [4] MICROWAVE-ASSISTED ORGANIC-REACTIONS
    CADDICK, S
    [J]. TETRAHEDRON, 1995, 51 (38) : 10403 - 10432
  • [5] Microwave assisted combinatorial chemistry synthesis of substituted pyridines
    Cotterill, IC
    Usyatinsky, AY
    Arnold, JM
    Clark, DS
    Dordick, JS
    Michels, PC
    Khmelnitsky, YL
    [J]. TETRAHEDRON LETTERS, 1998, 39 (10) : 1117 - 1120
  • [6] Microwave assisted synthesis of chiral imidazolyl and pyrazolyl alcohols
    Glas, H
    Thiel, WR
    [J]. TETRAHEDRON LETTERS, 1998, 39 (31) : 5509 - 5510
  • [7] KRIEG B, 1967, Z NATURFORSCH PT B, VB 22, P132
  • [8] Application of basic clays in microwave activated Michael additions: Preparation of N-substituted imidazoles
    MartinAranda, RM
    VicenteRodriguez, MA
    LopezPestana, JM
    LopezPeinado, AJ
    Jerez, A
    LopezGonzalez, JDD
    BanaresMunoz, MA
    [J]. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 1997, 124 (2-3) : 115 - 121
  • [9] Reddy ACS, 1997, TETRAHEDRON, V53, P5847
  • [10] Imidazole libraries on solid support
    Sarshar, S
    Siev, D
    Mjalli, AMM
    [J]. TETRAHEDRON LETTERS, 1996, 37 (06) : 835 - 838
12