Microwave-assisted synthesis of substituted imidazoles on a solid support under solvent-free conditions

被引：227
|
作者：
Usyatinsky, AY [1 ]
Khmelnitsky, YL [1 ]
机构：
[1] Albany Mol Res Inc, EnzyMed Div, Iowa City, IA 52242 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 26期
关键词：
microwave chemistry; solvent-free synthesis; substituted imidazoles; combinatorial synthesis;
D O I：
10.1016/S0040-4039(00)00771-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The solvent-free microwave-assisted synthesis of 2,4,5-substituted and 1,2,4,5-substituted imidazoles is reported. Imidazoles are obtained as a result of the condensation of a 1,2-dicarbonyl compound with an aldehyde and an amine using acidic alumina impregnated with ammonium acetate as the solid support. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：5031 / 5034
页数：4
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