Microwave-assisted synthesis of substituted imidazoles on a solid support under solvent-free conditions

被引：229

作者：

Usyatinsky, AY ^{[1
]}

Khmelnitsky, YL ^{[1
]}

机构：

[1] Albany Mol Res Inc, EnzyMed Div, Iowa City, IA 52242 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 26期

关键词：

microwave chemistry; solvent-free synthesis; substituted imidazoles; combinatorial synthesis;

D O I：

10.1016/S0040-4039(00)00771-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solvent-free microwave-assisted synthesis of 2,4,5-substituted and 1,2,4,5-substituted imidazoles is reported. Imidazoles are obtained as a result of the condensation of a 1,2-dicarbonyl compound with an aldehyde and an amine using acidic alumina impregnated with ammonium acetate as the solid support. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5031 / 5034

页数：4

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