Spatial-Temporal Patterns of Retinal Waves Underlying Activity-Dependent Refinement of Retinofugal Projections
被引:109
作者:
Stafford, Ben K.
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Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USAUniv Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
Stafford, Ben K.
[2
]
Sher, Alexander
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Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
Univ Calif Santa Cruz, Dept Phys, Santa Cruz, CA 95064 USAUniv Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
Sher, Alexander
[1
,3
]
Litke, Alan M.
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Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USAUniv Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
Litke, Alan M.
[1
]
Feldheim, David A.
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Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USAUniv Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
Feldheim, David A.
[2
]
机构:
[1] Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA
[3] Univ Calif Santa Cruz, Dept Phys, Santa Cruz, CA 95064 USA
During development, retinal axons project coarsely within their visual targets before refining to form organized synaptic connections. Spontaneous retinal activity, in the form of acetylcholine-driven retinal waves, is proposed to be necessary for establishing these projection patterns. In particular, both axonal terminations of retinal ganglion cells (RGCs) and the size of receptive fields of target neurons are larger in mice that lack the beta 2 subunit of the nicotinic acetylcholine receptor (beta 2KO). Here, using a large-scale, high-density multielectrode array to record activity from hundreds of RGCs simultaneously, we present analysis of early postnatal retinal activity from both wild-type (WT) and beta 2KO retinas. We find that beta 2KO retinas have correlated patterns of activity, but many aspects of these patterns differ from those of WT retina. Quantitative analysis suggests that wave directionality, coupled with short-range correlated bursting patterns of RGCs, work together to refine retinofugal projections.
机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Cang, JH
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Rentería, RC
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Rentería, RC
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Kaneko, M
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Kaneko, M
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Liu, XR
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Liu, XR
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Copenhagen, DR
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Copenhagen, DR
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Stryker, MP
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Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USAUniv Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Cang, JH
;
Rentería, RC
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h-index: 0
机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Rentería, RC
;
Kaneko, M
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Kaneko, M
;
Liu, XR
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Liu, XR
;
Copenhagen, DR
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机构:Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA
Copenhagen, DR
;
Stryker, MP
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机构:
Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USAUniv Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, Dept Physiol, San Francisco, CA 94143 USA