Spatial-Temporal Patterns of Retinal Waves Underlying Activity-Dependent Refinement of Retinofugal Projections

被引:109
作者
Stafford, Ben K. [2 ]
Sher, Alexander [1 ,3 ]
Litke, Alan M. [1 ]
Feldheim, David A. [2 ]
机构
[1] Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA
[2] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA
[3] Univ Calif Santa Cruz, Dept Phys, Santa Cruz, CA 95064 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
NICOTINIC ACETYLCHOLINE-RECEPTOR; EYE-SPECIFIC SEGREGATION; DEVELOPING MAMMALIAN RETINA; RETINOTOPIC MAP REFINEMENT; MICE LACKING; SUPERIOR COLLICULUS; RETINOGENICULATE PROJECTIONS; VISUAL EXPERIENCE; ACTION-POTENTIALS; INSTRUCTIVE ROLE;
D O I
10.1016/j.neuron.2009.09.021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
During development, retinal axons project coarsely within their visual targets before refining to form organized synaptic connections. Spontaneous retinal activity, in the form of acetylcholine-driven retinal waves, is proposed to be necessary for establishing these projection patterns. In particular, both axonal terminations of retinal ganglion cells (RGCs) and the size of receptive fields of target neurons are larger in mice that lack the beta 2 subunit of the nicotinic acetylcholine receptor (beta 2KO). Here, using a large-scale, high-density multielectrode array to record activity from hundreds of RGCs simultaneously, we present analysis of early postnatal retinal activity from both wild-type (WT) and beta 2KO retinas. We find that beta 2KO retinas have correlated patterns of activity, but many aspects of these patterns differ from those of WT retina. Quantitative analysis suggests that wave directionality, coupled with short-range correlated bursting patterns of RGCs, work together to refine retinofugal projections.
引用
收藏
页码:200 / 212
页数:13
相关论文
共 54 条
[1]  
Bansal A, 2000, J NEUROSCI, V20, P7672
[2]   Neuronal pentraxins mediate synaptic refinement in the developing visual system [J].
Bjartmar, Lisa ;
Huberman, Andrew D. ;
Ullian, Erik M. ;
Renteria, Rene C. ;
Liu, Xiaoqin ;
Xu, Weifeng ;
Prezioso, Jennifer ;
Susman, Michael W. ;
Stellwagen, David ;
Stokes, Caleb C. ;
Cho, Richard ;
Worley, Paul ;
Malenka, Robert C. ;
Ball, Sherry ;
Peachey, Neal S. ;
Copenhagen, David ;
Chapman, Barbara ;
Nakamoto, Masaru ;
Barres, Ben A. ;
Perin, Mark S. .
JOURNAL OF NEUROSCIENCE, 2006, 26 (23) :6269-6281
[3]   The information content of spontaneous retinal waves [J].
Butts, DA ;
Rokhsar, DS .
JOURNAL OF NEUROSCIENCE, 2001, 21 (03) :961-973
[4]   A burst-based "Hebbian" learning rule at retinogenicu late synapses links retinal waves to activity-dependent refinement [J].
Butts, Daniel A. ;
Kanold, Patrick O. ;
Shatz, Carla J. .
PLOS BIOLOGY, 2007, 5 (03) :651-661
[5]   Development of precise maps in visual cortex requires patterned spontaneous activity in the retina [J].
Cang, JH ;
Rentería, RC ;
Kaneko, M ;
Liu, XR ;
Copenhagen, DR ;
Stryker, MP .
NEURON, 2005, 48 (05) :797-809
[6]   A reassessment of the role of activity in the formation of eye-specific retinogeniculate projections [J].
Chalupa, Leo M. .
BRAIN RESEARCH REVIEWS, 2007, 55 (02) :228-236
[7]   Natural variations in postpartum maternal care in inbred and outbred mice [J].
Champagne, Frances A. ;
Curley, James P. ;
Keverne, Eric B. ;
Bateson, Patrick P. G. .
PHYSIOLOGY & BEHAVIOR, 2007, 91 (2-3) :325-334
[8]   Developmental homeostasis of mouse retinocollicular synapses [J].
Chandrasekaran, Anand R. ;
Shah, Ruchir D. ;
Crair, Michael C. .
JOURNAL OF NEUROSCIENCE, 2007, 27 (07) :1746-1755
[9]   Evidence for an instructive role of retinal activity in retinotopic map refinement in the superior colliculus of the mouse [J].
Chandrasekaran, AR ;
Plas, DT ;
Gonzalez, E ;
Crair, MC .
JOURNAL OF NEUROSCIENCE, 2005, 25 (29) :6929-6938
[10]   Developmental remodeling of the retinogeniculate synapse [J].
Chen, CF ;
Regehr, WG .
NEURON, 2000, 28 (03) :955-966