Hypervirulence of a rough variant of the Mycobacterium abscessus type strain

被引：155
作者：
Catherinot, E.
Clarissou, J.
Etienne, G.
Ripoll, F.
Emile, J. -F.
Daffe, M.
Perronne, C.
Soudais, C.
Gaillard, J. -L.
Rottman, M.
机构：
[1] Hop Raymond Poincare, AP HP, Microbiol Lab, F-92380 Garches, France
[2] Hop Raymond Poincare, AP HP, Dept Med Aigue Specialisee, F-92380 Garches, France
[3] Univ Versailles St Quantin, Fac Med Paris, F-92380 Garches, France
[4] CNRS, UMR 5089, Inst Pharmacol Biol Struct, Dept Mecanismes Mol Infect Mycobacteriennes, F-31077 Toulouse, France
[5] Hop Ambroise Pare, AP HP, Lab Anatomopathol, F-92100 Boulogne, France
[6] Hop Necker Enfants Malad, AP HP, Unite Immunol & Hematol, F-75730 Paris 15, France
[7] Univ Paris 05, INSERM, U550, Fac Med Necker Enfants Malad,Lab Human Genet Infe, F-75730 Paris 15, France
来源：
INFECTION AND IMMUNITY | 2007年 / 75卷 / 02期
关键词：
D O I：
10.1128/IAI.00835-06
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
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收藏
页码：1055 / 1058
页数：4
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