Depression, isotretinoin, and folic acid: A practical review

被引：22

作者：

Abdelmaksoud, Ayman ^{[1
]}

Vojvodic, Aleksandra ^{[2
]}

Ayhan, Erhan ^{[3
]}

Donmezdil, Suleyman ^{[4
]}

Jovicevic, Tatjana Vlaskovic ^{[5
]}

Vojvodic, Petar ^{[5
]}

Lotti, Torello ^{[6
]}

Vestita, Michelangelo ^{[7
,8
]}

机构：

[1] Venerol & Leprol Hosp, Mansoura Dermatol, 5 Amien Alsamanoudy St,AbdelsalamAaref St, Mansoura, Egypt

[2] Mil Med Acad Belgrade, Dept Dermatol & Venereol, Belgrade, Serbia

[3] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Dermatol, Diyarbakir, Turkey

[4] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Psychiat, Diyarbakir, Turkey

[5] Clin Mental Disorders Dr Laza Lazarevic, Belgrade, Serbia

[6] Univ Rome G Marconi, Dept Dermatol, Rome, Italy

[7] Univ Bari, Dept Emergency & Organ Transplantat, Unit Plast & Reconstruct Surg, Bari, Italy

[8] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA

来源：

DERMATOLOGIC THERAPY | 2019年 / 32卷 / 06期

关键词：

depression; folic acid; low dose isotretinoin; QUALITY-OF-LIFE; NEUROTROPHIC FACTOR; ACNE; VITAMIN-B12; ASSOCIATION; ANXIETY; ANTIDEPRESSANT; METAANALYSIS; FOLATE; HEALTH;

D O I：

10.1111/dth.13104

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Isotretinoin (ISO) is a first-generation retinoid discovered in 1952 and approved by the FDA for the treatment of nodulocystic acne in 1982. The anti-inflammatory properties of ISO have found its use in disorders other than acne. ISO can create psychiatric problems, including depression and suicidal ideation. These neuropsychiatric problems are very similar to disorders secondary to hyperhomocysteinemia (HHcy), vitamin B12, and folic acid (vitamin B9) deficiencies. Given that previous literature suggested folate supplementation improved the efficacy of traditional antidepressant medications, clinicians may wish to consider folate supplementation for patients with depression or possible depressive symptoms, such as acne patients with genetic susceptibility. Brain-derived neurotrophic factor may be a cytokine-specific screening biomarker in immune-based antidepressive therapy.

引用

页数：5

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