Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

被引：90

作者：

Kakeya, H

Takahashi-Ando, N

Kimura, M

Onose, R

Yamaguchi, I

Osada, H

机构：

[1] RIKEN, Antibiot Lab, Wako, Saitama 3510198, Japan

[2] RIKEN, Plant Sci Ctr, Lab Remediat Res, Wako, Saitama 3510198, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2002年 / 66卷 / 12期

关键词：

biotransformation; zearalenone; mycotoxins; microorganisms; detoxification;

D O I：

10.1271/bbb.66.2723

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell proliferation assay.

引用

页码：2723 / 2726

页数：4

共 24 条

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