Proteomic contributions to our understanding of vaccine and immune responses

被引:26
作者
Galassie, Allison C. [1 ]
Link, Andrew J. [1 ,2 ,3 ]
机构
[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA
基金
美国国家卫生研究院;
关键词
Systems biology; Vaccine; Vaccinology; OUTER-MEMBRANE PROTEINS; DENGUE VIRUS-INFECTION; YELLOW-FEVER VACCINE; MASS-SPECTROMETRY; MYCOBACTERIUM-TUBERCULOSIS; SYSTEMS BIOLOGY; DNA VACCINES; INFLUENZA-A; T-CELLS; CANDIDATE PROTEINS;
D O I
10.1002/prca.201500054
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Vaccines are one of the greatest public health successes; yet, due to the empirical nature of vaccine design, we have an incomplete understanding of how the genes and proteins induced by vaccines contribute to the development of both protective innate and adaptive immune responses. While the advent of genomics has enabled new vaccine development and facilitated understanding of the immune response, proteomics identifies potentially new vaccine antigens with increasing speed and sensitivity. In addition, as proteomics is complementary to transcriptomic approaches, a combination of both approaches provides a more comprehensive view of the immune response after vaccination via systems vaccinology. This review details the advances that proteomic strategies have made in vaccine development and reviews how proteomics contributes to the development of a more complete understanding of human vaccines and immune responses.
引用
收藏
页码:972 / 989
页数:18
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