Synthesis of 1,11-Dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with Potential Topoisomerase I Inhibitory Activity

被引：7

作者：

Delot, Marc ^{[1
]}

Carato, Pascal ^{[1
]}

Furman, Christophe ^{[2
]}

Lemoine, Amelie ^{[2
]}

Lebegue, Nicolas ^{[1
]}

Berthelot, Pascal ^{[1
]}

Yous, Said ^{[1
]}

机构：

[1] Univ Lille Nord France, Fac Pharm, Chim Therapeut Lab, EA 1043, F-59006 Lille, France

[2] Univ Lille Nord France, Inst Chim Pharmaceut Albert Lespagnol, EA 2692, IFR 114, F-59006 Lille, France

来源：

SYNTHESIS-STUTTGART | 2009年 / 22期

关键词：

alkaloids; heterocycles; cyclizations; condensation; fused-ring systems; ALCL3-DMF REAGENT; DERIVATIVES; CAMPTOTHECIN;

D O I：

10.1055/s-0029-1217007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 1,11-dihydro-2H-[1,3]oxazolo[4',5':5,6]indeno[1,2-b]quinolin-2-ones were prepared by means of Friedlander condensations. The starting materials for the preparations were commercial substituted-2-aminoacetophenones and various 5,6-dihydro-2H-indeno [5,6-d] [1,3]oxazole-2,7(3H)-diones that were synthesized from 2(3H)-benzoxazolones or their N-methyl analogues.

引用

页码：3819 / 3822

页数：4

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