Roles of pleiotrophin in tumor growth and angiogenesis

被引：52

作者：

Papadimitriou, Evangelia ^{[1
]}

Mikelis, Constantinos ^{[1
]}

Lampropoulou, Evgenia ^{[1
]}

Koutsioumpa, Marina ^{[1
]}

Theochari, Katerina ^{[1
]}

Tsirmoula, Sotiria ^{[1
]}

Theodoropoulou, Christina ^{[1
]}

Lamprou, Margarita ^{[1
]}

Sfaelou, Evanthia ^{[1
]}

Vourtsis, Dionyssios ^{[1
]}

Boudouris, Panagiotis ^{[1
]}

机构：

[1] Univ Patras, Dept Pharm, Mol Pharmacol Lab, Patras 26504, Greece

来源：

EUROPEAN CYTOKINE NETWORK | 2009年 / 20卷 / 04期

关键词：

angiogenesis; cancer; endothelial cells; pleiotrophin; receptor protein tyrosine phosphatase beta/zeta; integrins; PROTEIN-TYROSINE-PHOSPHATASE; AFFIN REGULATORY PEPTIDE; ANAPLASTIC LYMPHOMA KINASE; MOLECULE HB-GAM; PROSTATE-CANCER CELLS; BINDING NEUROTROPHIC FACTOR; SULFATE HYBRID CHAINS; HUMAN BREAST-CANCER; SURFACE-EXPRESSED NUCLEOLIN; N-SYNDECAN SYNDECAN-3;

D O I：

10.1684/ecn.2009.0172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many questions remain unanswered, particularly concerning the receptors and the signaling pathways involved. In this review, we briefly introduce PTN, and summarize data on its involvement in tumor growth and angiogenesis, and on what is known to date concerning the receptors and pathways involved.

引用

页码：180 / 190

页数：11

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