Non Coding RNA Molecules as Potential Biomarkers in Breast Cancer

被引：31
作者：
De Leeneer, Kim [1 ]
Claes, Kathleen [1 ]
机构：
[1] Univ Ghent, Ctr Med Genet Ghent, B-9000 Ghent, Belgium
来源：
ADVANCES IN CANCER BIOMARKERS: FROM BIOCHEMISTRY TO CLINIC FOR A CRITICAL REVISION | 2015年 / 867卷
关键词：
BC200; Circulating miRNAs; Her2neu/ERBB2; let-7; miRNA; Long non coding RNA; microRNA; miR-10b; miR-145; miR-16; miR-195; miR-200; family; miR-21; miR-29; miR-31; miR-335; miR451; miR-9; MiRNAS and breast cancer; LONG NONCODING RNAS; MIR-200; FAMILY; MICRORNA BIOGENESIS; TUMOR-METASTASIS; DOWN-REGULATION; E-CADHERIN; BC200; RNA; EXPRESSION; GENE; SERUM;
D O I：
10.1007/978-94-017-7215-0_16
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pursuit of minimally invasive biomarkers is a challenging but exciting area of research. Clearly, such markers would need to be sensitive and specific enough to aid in the detection of breast cancer at an early stage, would monitor progression of the disease, and could predict the individual patient's response to treatment. Unfortunately, to date, markers with such characteristics have not made it to the clinic for breast cancer. Past years, many studies indicated that the non-coding part of our genome (the so called 'junk' DNA), may be an ideal source for these biomarkers. In this chapter, the potential use of microRNAs and long non-coding RNAs as biomarkers will be discussed.
引用
收藏
页码：263 / 275
页数：13
相关论文
共 123 条
[31]   Extracellular microRNA: A new source of biomarkers [J].
Etheridge, Alton ;
Lee, Inyoul ;
Hood, Leroy ;
Galas, David ;
Wang, Kai .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 717 (1-2) :85-90
[32]   The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator [J].
Feng, Jianchi ;
Bi, Chumming ;
Clark, Brian S. ;
Mady, Rina ;
Shah, Palak ;
Kohtz, Jhumku D. .
GENES & DEVELOPMENT, 2006, 20 (11) :1470-1484
[33]   Most mammalian mRNAs are conserved targets of microRNAs [J].
Friedman, Robin C. ;
Farh, Kyle Kai-How ;
Burge, Christopher B. ;
Bartel, David P. .
GENOME RESEARCH, 2009, 19 (01) :92-105
[34]   Characterization of microRNA expression levels and their biological correlates in human cancer cell lines [J].
Gaur, Arti ;
Jewell, David A. ;
Liang, Yu ;
Ridzon, Dana ;
Moore, Jason H. ;
Chen, Caifu ;
Ambros, Victor R. ;
Israel, Mark A. .
CANCER RESEARCH, 2007, 67 (06) :2456-2468
[35]   MicroRNA-10b and breast cancer metastasis [J].
Gee, Harriet E. ;
Camps, Carme ;
Buffa, Francesca M. ;
Colella, Stefano ;
Sheldon, Helen ;
Gleadle, Jonathan M. ;
Ragoussis, Jiannis ;
Harris, Adrian L. .
NATURE, 2008, 455 (7216) :E8-E9
[36]   Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression [J].
Gibbons, Don L. ;
Lin, Wei ;
Creighton, Chad J. ;
Rizvi, Zain H. ;
Gregory, Philip A. ;
Goodall, Gregory J. ;
Thilaganathan, Nishan ;
Du, Liqin ;
Zhang, Yiqun ;
Pertsemlidis, Alexander ;
Kurie, Jonathan M. .
GENES & DEVELOPMENT, 2009, 23 (18) :2140-2151
[37]   Serum MicroRNAs Are Promising Novel Biomarkers [J].
Gilad, Shlomit ;
Meiri, Eti ;
Yogev, Yariv ;
Benjamin, Sima ;
Lebanony, Danit ;
Yerushalmi, Noga ;
Benjamin, Hila ;
Kushnir, Michal ;
Cholakh, Hila ;
Melamed, Nir ;
Bentwich, Zvi ;
Hod, Moshe ;
Goren, Yaron ;
Chajut, Ayelet .
PLOS ONE, 2008, 3 (09)
[38]   The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 [J].
Gregory, Philip A. ;
Bert, Andrew G. ;
Paterson, Emily L. ;
Barry, Simon C. ;
Tsykin, Anna ;
Farshid, Gelareh ;
Vadas, Mathew A. ;
Khew-Goodall, Yeesim ;
Goodall, Gregory J. .
NATURE CELL BIOLOGY, 2008, 10 (05) :593-601
[39]  
Gregory RI, 2005, CELL, V123, P631, DOI 10.1016/j.cell.2005.10.022
[40]   The Microprocessor complex mediates the genesis of microRNAs [J].
Gregory, RI ;
Yan, KP ;
Amuthan, G ;
Chendrimada, T ;
Doratotaj, B ;
Cooch, N ;
Shiekhattar, R .
NATURE, 2004, 432 (7014) :235-240
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