Evolutionary analysis of HA and NS1 genes of H5N1 influenza viruses in 2004-2005 epidemics

被引：3

作者：

Ciccozzi, Massimo ^{[1
]}

Montieri, Stefania ^{[1
]}

Facchini, Marzia ^{[1
]}

Rezza, Giovanni ^{[1
]}

Donatelli, Isabella ^{[1
]}

Campitelli, Laura ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immunomed Dis, I-00161 Rome, Italy

来源：

AVIAN DISEASES | 2007年 / 51卷 / 01期

关键词：

avian influenza; H5N1; virus evolution; bioinformatics; RECEPTOR SPECIFICITY; MODELS; SITES; BIRDS;

D O I：

10.1637/7620-042606R.1

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

H5N1 avian influenza viruses circulating in early 2004 in eastern Asia appeared to be under strong purifying selection, except for the hemagglutinin (HA) and nonstructural 1 (NS1) genes, where few amino acid positions were found under positive selection pressure. To evaluate whether the widespread circulation of the H5N1 viruses in the following years was accompanied by a change in the evolution of the HA and NS1, phylogenetic and positive selection analyses were performed on 89 HA and 57 NS1 sequences. Results showed that the number of HA positively selected sites decreased compared to 2004; no selection pressure for NS1 was found. These findings suggest a possible change in the adaptation of the H5N1 virus to birds.

引用

页码：455 / 460

页数：6

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