The effect of hyaluronic acid on brushite cement cohesion

被引：53

作者：

Alkhraisat, M. H. ^{[1
]}

Rueda, C. ^{[1
]}

Marino, F. T. ^{[2
]}

Torres, J. ^{[3
]}

Jerez, L. B. ^{[4
]}

Gbureck, U. ^{[5
]}

Cabarcos, E. L. ^{[1
]}

机构：

[1] UCM, Dept Quim Fis 2, Fac Farm, Madrid 28040, Spain

[2] McGill Univ, Fac Dent, Montreal, PQ, Canada

[3] URJC, Dept Ciencias Salud 3, Fac Ciencias Salud, Alcorcon Madrid, Spain

[4] UCM, Dept Estomatol 3, Fac Odontol, Madrid 28040, Spain

[5] Univ Wurzburg, Dept Funct Mat Med & Dent, D-97070 Wurzburg, Germany

来源：

ACTA BIOMATERIALIA | 2009年 / 5卷 / 08期

关键词：

Brushite; Calcium phosphate cement; Cohesion; Hyaluronic acid; Molecular weight; CALCIUM-PHOSPHATE CEMENT; BIOMECHANICAL EVALUATION; CRYSTAL-STRUCTURE; BONE; POLYMETHYLMETHACRYLATE; VERTEBROPLASTY; HYDROXYAPATITE; INHIBITION; COMPOSITE;

D O I：

10.1016/j.actbio.2009.04.001

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The improvement of calcium phosphate cement (CPC) cohesion is essential for its application in highly blood perfused regions. This study reports the effectiveness of hyaluronic acids of different molecular weights in the enhancement of brushite cement cohesion. The cement was prepared using a powder phase composed of a mixture of beta-tricalcium phosphate and monocalcium phosphate monohydrate, whereas the liquid phase was formed by 0.5 M citric acid solution modified by the addition of hyaluronic acid of different molecular weights. It was found that medium and high molecular weight hyaluronic acid enhances the cement cohesion and scarcely affects the cement mechanical properties. However, concentrations >0.5% (w/v) were less efficient to prevent the cement disintegration. It is concluded that hyaluronic acid could be applied efficiently to reduce brushite cement disintegration. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：3150 / 3156

页数：7

共 47 条

[1] Beta-tricalcium phosphate release from brushite cement surface [J].

Alkhraisat, M. Hamdan ;

Marino, F. Tamimi ;

Retama, J. Rubio ;

Jerez, L. Blanco ;

Lopez-Cabarcos, E. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2008, 84A (03) :710-717

[2] In vivo behavior of three different injectable hydraulic calcium phosphate cements [J].

Apelt, D ;

Theiss, F ;

El-Warrak, AO ;

Zlinszky, K ;

Bettschart-Wolfisberger, R ;

Bohner, M ;

Matter, S ;

Auer, JA ;

von Rechenberg, B .

BIOMATERIALS, 2004, 25 (7-8) :1439-1451

[3] The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures [J].

Bai, B ;

Jazrawi, LM ;

Kummer, FJ ;

Spivak, JM .

SPINE, 1999, 24 (15) :1521-1526

[4] Rheological characterization of concentrated aqueous β-tricalcium phosphate suspensions:: The effect of liquid-to-powder ratio, milling time, and additives [J].

Baroud, G ;

Cayer, E ;

Bohner, M .

ACTA BIOMATERIALIA, 2005, 1 (03) :357-363

[5] Biomechanical evaluation of a new bone cement for use in vertebroplasty [J].

Belkoff, SM ;

Mathis, JM ;

Erbe, EM ;

Fenton, DC .

SPINE, 2000, 25 (09) :1061-1064

[6] Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty [J].

Belkoff, SM ;

Molloy, S .

SPINE, 2003, 28 (14) :1555-1559

[7] Adjacent vertebral failure after vertebroplasty - A biomechanical investigation [J].

Berlemann, U ;

Ferguson, SJ ;

Nolte, LP ;

Hein, PF .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2002, 84B (05) :748-752

[8]

BERNARDS CM, 2004, P 50 ANN M ORTH RES

[9] Theoretical and experimental approach to test the cohesion of calcium phosphate pastes [J].

Bohner, M. ;

Doebelin, N. ;

Baroud, G. .

EUROPEAN CELLS & MATERIALS, 2006, 12 :26-35

[10] Technological issues for the development of more efficient calcium phosphate bone cements: A critical assessment [J].

Bohner, M ;

Gbureck, U ;

Barralet, JE .

BIOMATERIALS, 2005, 26 (33) :6423-6429

← 1 2 3 4 5 →