Synthesis of pharmaceutically important 1,3,4-thiadiazole and imidazolinone derivatives as antimicrobials

Thiosemicarbazide of 6-chloro-2-aminobenzothiozole on cyclization with different aromatic carboxylic acids in POCl3 and substituted azlactones in pyridine provide the corresponding 2-aryl-5-(6'chloro-1',3'-benzothiazole-2-yl-amino)-1,3,4- thiadiazoles 2a-j and 4-(4'-arylidene) -2-phenyl-1-(6'-chloro-1',3'-benzothiazol-2-yl-thiourido)-4,5-dihydroimidazolin-5-ones 3a-e. The compounds have been characterized by elemental analysis. IR H-1 NMR and mass spectral data. All the compounds have been evaluated in vitro for their antimicrobial activities against microbes and show significant activity.