Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

被引：54

作者：

Nagatake, Takahiro ^{[1
,5
,6
]}

Fukuyama, Satoshi ^{[1
]}

Kim, Dong-Young ^{[1
,7
]}

Goda, Kaoru ^{[1
]}

Igarashi, Osamu ^{[1
]}

Sato, Shintaro ^{[1
]}

Nochi, Tomonori ^{[1
]}

Sagara, Hiroshi ^{[2
]}

Yokota, Yoshifumi ^{[8
]}

Jetten, Anton M. ^{[9
]}

Kaisho, Tsuneyasu ^{[10
]}

Akira, Shizuo ^{[11
]}

Mimuro, Hitomi ^{[3
]}

Sasakawa, Chihiro ^{[3
]}

Fukui, Yoshinori ^{[12
]}

Fujihashi, Kohtaro ^{[13
]}

Akiyama, Taishin ^{[4
]}

Inoue, Jun-ichiro ^{[4
]}

Penninger, Josef M. ^{[14
]}

Kunisawa, Jun ^{[1
,15
]}

Kiyono, Hiroshi ^{[1
,5
,6
,13
,15
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Div Mucosal Immunol, Dept Microbiol & Immunol,Minato Ku, Tokyo 1088639, Japan

[2] Univ Tokyo, Med Prote Lab, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan

[3] Univ Tokyo, Inst Med Sci, Div Bacterial Infect, Dept Microbiol & Immunol,Minato Ku, Tokyo 1088639, Japan

[4] Univ Tokyo, Inst Med Sci, Div Cellular & Mol Biol, Minato Ku, Tokyo 1088639, Japan

[5] Univ Tokyo, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

[6] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan

[7] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol, Seoul 110744, South Korea

[8] Univ Fukui, Sch Med, Dept Mol Genet, Eiheiji, Fukui 9101193, Japan

[9] NIEHS, Cell Biol Sect, Lab Resp Biol, NIH, Res Triangle Pk, NC 27709 USA

[10] Inst Phys & Chem Res, Res Ctr Allergy & Immunol, Host Def Lab, Tsurumi Ku, Kanagawa 2300045, Japan

[11] Osaka Univ, Host Def Lab, World Premier Int Res Ctr, Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[12] Kyushu Univ, Div Immunogenet, Dept Immunobiol & Neurosci, Med Inst Bioregulat, Fukuoka 8128582, Japan

[13] Univ Alabama, Dept Pediat Dent, Immunobiol Vaccine Ctr, Birmingham, AL 35294 USA

[14] Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, Austria

[15] Univ Tokyo, Grad Sch Frontier Sci, Chiba 2778561, Japan

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 11期

基金：

日本学术振兴会;

关键词：

TISSUE-INDUCER CELLS; HIGH ENDOTHELIAL VENULES; ORPHAN RECEPTOR-GAMMA; CUTTING EDGE; LYMPHOTOXIN-ALPHA; PSEUDOMONAS-AERUGINOSA; NODE ORGANOGENESIS; ORGAN DEVELOPMENT; GERMINAL-CENTERS; LACRIMAL GLANDS;

D O I：

10.1084/jem.20091436

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The eye is protected by the ocular immunosurveillance system. We show that tear duct associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/ differentiation 2, retinoic acid-related orphan receptor gamma t, lymphotoxin (LT) alpha 1 beta 2-LT beta R, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.

引用

页码：2351 / 2364

页数：14

共 3 条

[1] Presence of Id2-and RORγt-independent lymphoid tissue organogenesis
Nagatake, Takahiro
Fukuyama, Satoshi
Kim, Dong-Young
Takamura, Kaoru
Kiyono, Hiroshi
JOURNAL OF IMMUNOLOGY, 2007, 178
[2] Genesis of tear duct-associated lymphoid tissue is independent of Id2, RORγt but requires Cbfβ2 transcriptional regulator
Nagatake, Takahiro
Fukuyama, Satoshi
Tachibana, Masashi
Taniuchi, Ichiro
Kim, Dong-Young
Takamura, Kaoru
Sato, Shintaro
Kunisawa, Jun
Kiyono, Hiroshi
FASEB JOURNAL, 2008, 22
[3] Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3-CD4+CD45+ cells
Fukuyama, S
Hiroi, T
Yokota, Y
Rennert, PD
Yanagita, M
Kinoshita, N
Terawaki, S
Shikina, T
Yamamoto, M
Kurono, Y
Kiyono, H
IMMUNITY, 2002, 17 (01) : 31 - 40

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