Three-dimensional structure of the Ras-interacting domain of RalGDS

被引：73
作者：
Huang, L
Weng, XW
Hofer, F
Martin, GS
Kim, SH
机构：
[1] UNIV CALIF BERKELEY,LAWRENCE BERKELEY NATL LAB,DEPT CHEM & STRUCT BIOL,DIV EO,BERKELEY,CA 94720
[2] UNIV CALIF BERKELEY,DEPT MOL & CELL BIOL,BERKELEY,CA 94720
来源：
NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 08期
关键词：
D O I：
10.1038/nsb0897-609
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Ras-interacting domains of the the protein-kinase Raf and the Ral guanine nucleotide dissociation stimulator, RalGDS, lack extensive sequence similarity, but their overall three-dimensional structures are very similar to each other. Mutational analysis indicated that three residues in the RalGDS domain are critical for its interaction with Ras.
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收藏
页码：609 / 615
页数：7
相关论文
共 46 条
[1]   CHARACTERIZATION OF A GUANINE-NUCLEOTIDE DISSOCIATION STIMULATOR FOR A RAS-RELATED GTPASE [J].
ALBRIGHT, CF ;
GIDDINGS, BW ;
LIU, J ;
VITO, M ;
WEINBERG, RA .
EMBO JOURNAL, 1993, 12 (01) :339-347
[2]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[3]  
Bartel P, 1993, CELLULAR INTERACTION, P153
[4]   Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo [J].
Block, C ;
Janknecht, R ;
Herrmann, C ;
Nassar, N ;
Wittinghofer, A .
NATURE STRUCTURAL BIOLOGY, 1996, 3 (03) :244-251
[5]   PROTEINS REGULATING RAS AND ITS RELATIVES [J].
BOGUSKI, MS ;
MCCORMICK, F .
NATURE, 1993, 366 (6456) :643-654
[6]  
Brunger A. T., 1993, X PLOR SYSTEM XRAY C
[7]   FREE R-VALUE - A NOVEL STATISTICAL QUANTITY FOR ASSESSING THE ACCURACY OF CRYSTAL-STRUCTURES [J].
BRUNGER, AT .
NATURE, 1992, 355 (6359) :472-475
[8]   ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE BY V-RAF IN NIH 3T3 CELLS AND INVITRO [J].
DENT, P ;
HASER, W ;
HAYSTEAD, TAJ ;
VINCENT, LA ;
ROBERTS, TM ;
STURGILL, TW .
SCIENCE, 1992, 257 (5075) :1404-1407
[9]   CRYSTAL-STRUCTURE OF A STREPTOCOCCAL PROTEIN-G DOMAIN BOUND TO AN FAB FRAGMENT [J].
DERRICK, JP ;
WIGLEY, DB .
NATURE, 1992, 359 (6397) :752-754
[10]   SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1 AND IDENTIFICATION OF ITS RAS INTERACTION SURFACE [J].
EMERSON, SD ;
MADISON, VS ;
PALERMO, RE ;
WAUGH, DS ;
SCHEFFLER, JE ;
TSAO, KL ;
KIEFER, SE ;
LIU, SP ;
FRY, DC .
BIOCHEMISTRY, 1995, 34 (21) :6911-6918
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