Clinical evaluation of TOF versus non-TOF on PET artifacts in simultaneous PET/MR: a dual centre experience

被引：16

作者：

ter Voert, Edwin E. G. W. ^{[1
,2
]}

Veit-Haibach, Patrick ^{[1
,2
,3
]}

Ahn, Sangtae ^{[4
]}

Wiesinger, Florian ^{[5
]}

Khalighi, M. Mehdi ^{[6
]}

Levin, Craig S. ^{[7
]}

Iagaru, Andrei H. ^{[8
]}

Zaharchuk, Greg ^{[9
]}

Huellner, Martin ^{[1
,2
,10
]}

Delso, Gaspar ^{[6
]}

机构：

[1] Univ Hosp Zurich, Dept Nucl Med, Ramistr 100, CH-8091 Zurich, Switzerland

[2] Univ Zurich, Zurich, Switzerland

[3] Univ Hosp Zurich, Dept Diagnost & Intervent Radiol, Zurich, Switzerland

[4] GE Global Res, Niskayuna, NY USA

[5] GE Global Res, Munich, Germany

[6] GE Healthcare, Waukesha, WI USA

[7] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA

[8] Stanford Univ, Dept Radiol, Div Nucl Med & Mol Imaging, Stanford, CA 94305 USA

[9] Stanford Univ, Dept Radiol, Neuroradiol, Stanford, CA 94305 USA

[10] Univ Hosp Zurich, Dept Neuroradiol, Zurich, Switzerland

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2017年 / 44卷 / 07期

关键词：

Time-of-flight; Artifacts; Positron emission tomography; Magnetic resonance imaging; Clinical research; TIME-OF-FLIGHT; ATTENUATION CORRECTION; WHOLE-BODY; IMAGE-RECONSTRUCTION; EMISSION; INFORMATION; SEGMENTATION; SYSTEM; METAL; TOMOGRAPHY;

D O I：

10.1007/s00259-017-3619-2

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Our objective was to determine clinically the value of time-of-flight (TOF) information in reducing PET artifacts and improving PET image quality and accuracy in simultaneous TOF PET/MR scanning. A total 65 patients who underwent a comparative scan in a simultaneous TOF PET/MR scanner were included. TOF and non-TOF PET images were reconstructed, clinically examined, compared and scored. PET imaging artifacts were categorized as large or small implant-related artifacts, as dental implant-related artifacts, and as implant-unrelated artifacts. Differences in image quality, especially those related to (implant) artifacts, were assessed using a scale ranging from 0 (no artifact) to 4 (severe artifact). A total of 87 image artifacts were found and evaluated. Four patients had large and eight patients small implant-related artifacts, 27 patients had dental implants/fillings, and 48 patients had implant-unrelated artifacts. The average score was 1.14 +/- 0.82 for non-TOF PET images and 0.53 +/- 0.66 for TOF images (p < 0.01) indicating that artifacts were less noticeable when TOF information was included. Our study indicates that PET image artifacts are significantly mitigated with integration of TOF information in simultaneous PET/MR. The impact is predominantly seen in patients with significant artifacts due to metal implants.

引用

页码：1223 / 1233

页数：11

共 53 条

[1] Application and Evaluation of a Measured Spatially Variant System Model for PET Image Reconstruction [J].

Alessio, Adam M. ;

Stearns, Charles W. ;

Tong, Shan ;

Ross, Steven G. ;

Kohlmyer, Steve ;

Ganin, Alex ;

Kinahan, Paul E. .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 2010, 29 (03) :938-949

[2] Combined PET/MR imaging in neurology: MR-based attenuation correction implies a strong spatial bias when ignoring bone [J].

Andersen, Flemming Littrup ;

Ladefoged, Claes Nohr ;

Beyer, Thomas ;

Keller, Sune Hogild ;

Hansen, Adam Espe ;

Hojgaard, Liselotte ;

Kjaer, Andreas ;

Law, Ian ;

Holm, Soren .

NEUROIMAGE, 2014, 84 :206-216

[3]

Antoch G, 2004, J NUCL MED, V45, p56S

[4]

Bai CY, 2003, J NUCL MED, V44, P1855

[5] Accurate PET/MR Quantification Using Time of Flight MLAA Image Reconstruction [J].

Boellaard, R. ;

Hofman, M. B. M. ;

Hoekstra, O. S. ;

Lammertsma, A. A. .

MOLECULAR IMAGING AND BIOLOGY, 2014, 16 (04) :469-477

[6] Segmentation-Based Attenuation Correction in Positron Emission Tomography/Magnetic Resonance Erroneous Tissue Identification and Its Impact on Positron Emission Tomography Interpretation [J].

Brendle, Cornelia ;

Schmidt, Holger ;

Oergel, Anja ;

Bezrukov, Ilja ;

Mueller, Mark ;

Schraml, Christina ;

Pfannenberg, Christina ;

la Fougere, Christian ;

Nikolaou, Konstantin ;

Schwenzer, Nina .

INVESTIGATIVE RADIOLOGY, 2015, 50 (05) :339-346

[7] MR-Based Attenuation Correction Using Ultrashort-Echo-Time Pulse Sequences in Dementia Patients [J].

Cabello, Jorge ;

Lukas, Mathias ;

Foerster, Stefan ;

Pyka, Thomas ;

Nekolla, Stephan G. ;

Ziegler, Sibylle I. .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (03) :423-429

[8] MR imaging near metal with undersampled 3D radial UTE-MAVRIC sequences [J].

Carl, Michael ;

Koch, Kevin ;

Du, Jiang .

MAGNETIC RESONANCE IN MEDICINE, 2013, 69 (01) :27-36

[9] Focus on time-of-flight PET: the benefits of improved time resolution [J].

Conti, Maurizio .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2011, 38 (06) :1147-1157

[10] Why is TOF PET reconstruction a more robust method in the presence of inconsistent data? [J].

Conti, Maurizio .

PHYSICS IN MEDICINE AND BIOLOGY, 2011, 56 (01) :155-168

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