In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

被引：62

作者：

Watanabe, Kazuto ^{[1
]}

Harada-Shiba, Mariko ^{[2
]}

Suzuki, Akira ^{[2
]}

Gokuden, Risa ^{[1
]}

Kurihara, Ryohsuke ^{[1
]}

Sugao, Yusuke ^{[1
]}

Mori, Takeshi ^{[1
,3
]}

Katayama, Yoshiki ^{[1
,3
]}

Niidome, Takuro ^{[1
,3
,4
]}

机构：

[1] Kyushu Univ, Fac Engn, Dept Appl Chem, Fukuoka 8190395, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Biosci, Osaka 5658565, Japan

[3] Kyushu Univ, Ctr Future Chem, Fukuoka 8190395, Japan

[4] Japan Sci & Technol Corp, PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

MOLECULAR BIOSYSTEMS | 2009年 / 5卷 / 11期

基金：

日本学术振兴会;

关键词：

PLASMID DNA; RNAI THERAPEUTICS; GENE-EXPRESSION; INTERFERING RNA; VITRO; CARRIERS; CANCER; MICE;

D O I：

10.1039/b900880b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

引用

页码：1306 / 1310

页数：5

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