Combined calorimetric gas- and spore-based biosensor array for online monitoring and sterility assurance of gaseous hydrogen peroxide in aseptic filling machines

被引：15
作者：
Arreola, Julio [1 ,2 ]
Keusgen, Michael [2 ]
Wagner, Torsten [1 ,3 ]
Schoening, Michael J. [1 ,3 ]
机构：
[1] Aachen Univ Appl Sci, INB, Campus Julich, D-52428 Julich, Germany
[2] Philipps Univ Marburg, Inst Pharmaceut Chem, Marbacher Weg 6-10, D-35032 Marburg, Germany
[3] Res Ctr Julich GmbH, ICS 8, D-52425 Julich, Germany
来源：
BIOSENSORS & BIOELECTRONICS | 2019年 / 143卷
关键词：
Biosensor; Sterilization; Spore; Hydrogen peroxide; Aseptic filling machine; ATOMIC-FORCE MICROSCOPY; STERILIZATION METHODS; SENSOR; VAPOR; H2O2; TEMPERATURES; ANTHRACIS; SURFACES; EFFICACY; OXIDE;
D O I：
10.1016/j.bios.2019.111628
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A combined calorimetric gas- and spore-based biosensor array is presented in this work to monitor and evaluate the sterilization efficacy of gaseous hydrogen peroxide in aseptic filling machines. H2O2 has been successfully measured under industrial conditions. Furthermore, the effect of H2O2 on three different spore strains, namely Bacillus atrophaeus, Bacillus subtilis and Geobacillus stearothermophilus, has been investigated by means of SEM, AFM and impedimetric measurements. In addition, the sterilization efficacy of a spore-based biosensor and the functioning principle are addressed and discussed: the sensor array is convenient to be used in aseptic food industry to guarantee sterile packages.
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页数：8
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