An integrated console for capsule-based, automated organic synthesis

被引：25

作者：

Jiang, Tuo ^{[1
,2
]}

Bordi, Samuele ^{[1
]}

McMillan, Angus E. ^{[1
]}

Chen, Kuang-Yen ^{[1
]}

Saito, Fumito ^{[1
]}

Nichols, Paula L. ^{[1
,2
]}

Wanner, Benedikt M. ^{[1
,2
]}

Bode, Jeffrey W. ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Lab Far Organ Chem, Dept Chem & Appl Biasci, CH-803 Zurich, Switzerland

[2] Synple Chem AG, CH-8093 Zurich, Switzerland

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 20期

基金：

欧洲研究理事会;

关键词：

SNAP REAGENTS; SYSTEM; TOOLS;

D O I：

10.1039/d1sc01048d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The current laboratory practices of organic synthesis are labor intensive, impose safety and environmental hazards, and hamper the implementation of artificial intelligence guided drug discovery. Using a combination of reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two desirable reaction classes - the synthesis of saturated N-heterocycles and reductive amination - were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

引用

页码：6977 / 6982

页数：6

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