Facilitating Ir-Catalyzed C-H Alkynylation with Electrochemistry: Anodic Oxidation-Induced Reductive Elimination

被引：32

作者：

Ye, Xiaohan ^{[1
]}

Wang, Chenhuan ^{[1
]}

Zhang, Shuyao ^{[1
]}

Wei, Jingwen ^{[1
]}

Shan, Chuan ^{[1
]}

Wojtas, Lukasz ^{[1
]}

Xie, Yan ^{[2
]}

Shi, Xiaodong ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Quzhou Univ, Coll Chem & Mat Engn, Quzhou 324000, Peoples R China

来源：

ACS CATALYSIS | 2020年 / 10卷 / 20期

关键词：

C-H activation; alkynylation; electrochemistry; iridium; anodic oxidation; REMOVABLE DIRECTING GROUPS; BOND FUNCTIONALIZATIONS; TERMINAL ALKYNES; ARENES; ACTIVATION; MILD; ARYLATIONS; ANNULATION; EFFICIENT; HYDROGEN;

D O I：

10.1021/acscatal.0c03207

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An electrochemical approach in promoting directed C-H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallography) to promote reductive elimination, giving the desired coupling products in good yields (up to 95%) without the addition of any other external oxidants. This transformation is suitable for various directing groups with H-2 as the only byproduct, which warrants a high atom economy and practical oxidative C-C bond formation under mild conditions.

引用

页码：11693 / 11699

页数：7

共 98 条

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