Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations

被引：70

作者：

Pawlowski, Colin ^{[1
]}

Puranik, Arjun ^{[1
]}

Bandi, Hari ^{[1
]}

Venkatakrishnan, A. J. ^{[1
]}

Agarwal, Vineet ^{[1
]}

Kennedy, Richard ^{[2
]}

O'Horo, John C. ^{[2
]}

Gores, Gregory J. ^{[2
]}

Williams, Amy W. ^{[2
]}

Halamka, John ^{[2
]}

Badley, Andrew D. ^{[2
]}

Soundararajan, Venky ^{[1
]}

机构：

[1] Nference Inc, One Main St,Suite 400, Cambridge, MA 02142 USA

[2] Mayo Clin, Rochester, MN USA

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

VACCINES;

D O I：

10.1038/s41598-021-83641-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization records from 137,037 individuals who received SARS-CoV-2 PCR tests. We find that polio, Haemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), Varicella, pneumococcal conjugate (PCV13), Geriatric Flu, and hepatitis A/hepatitis B (HepA-HepB) vaccines administered in the past 1, 2, and 5 years are associated with decreased SARS-CoV-2 infection rates, even after adjusting for geographic SARS-CoV-2 incidence and testing rates, demographics, comorbidities, and number of other vaccinations. Furthermore, age, race/ethnicity, and blood group stratified analyses reveal significantly lower SARS-CoV-2 rate among black individuals who have taken the PCV13 vaccine, with relative risk of 0.45 at the 5 year time horizon (n: 653, 95% CI (0.32, 0.64), p-value: 6.9e-05). Overall, this study identifies existing approved vaccines which can be promising candidates for pre-clinical research and Randomized Clinical Trials towards combating COVID-19.

引用

页数：20

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