The expression of Smad signaling pathway in myocardium and potential therapeutic effects

被引：14
作者：
Duan, Yuping [1 ,2 ]
Zhu, Wei [1 ]
Liu, Min [2 ]
Ashraf, Muhammad [2 ]
Xu, Meifeng [2 ]
机构：
[1] Jiangsu Univ, Sch Med, Zhenjiang, Jiangsu, Peoples R China
[2] Univ Cincinnati, Med Ctr, Dept Pathol & Lab Med, 231 Albert Sabin Way, Cincinnati, OH 45267 USA
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2017年 / 32卷 / 07期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
Myocardial infarction; Smad; TGF-beta; BMP; BONE MORPHOGENETIC PROTEIN; GROWTH-FACTOR-BETA; ANGIOTENSIN-CONVERTING ENZYME; SMOOTH-MUSCLE-CELLS; TGF-BETA; CARDIAC FIBROSIS; HEART-FAILURE; PRESSURE-OVERLOAD; RECEPTOR BLOCKADE; HEPATIC-FIBROSIS;
D O I：
10.14670/HH-11-845
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Myocardial infarction (MI) is a life-threatening disease. The expression of Smad proteins in the ischemic myocardium changes significantly following myocardial infarction, suggesting a close relationship between Smad proteins and heart remodeling. Moreover, it is known that the expression of Smads is regulated by transforming growth factor-beta (TGF-beta) and bone morphogenetic proteins (BMP). Based on these findings, regulating the expression of Smad proteins by targeting TGF-beta and BMP in the ischemic myocardium may be considered to be a possible therapeutic strategy for the treatment of myocardial infarction.
引用
收藏
页码：651 / 659
页数：9
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