Effect of penetration enhancers on isosorbide dinitrate penetration through rat skin from a transdermal therapeutic system

被引：25

作者：

Gabiga, H ^{[1
]}

Cal, K ^{[1
]}

Janicki, S ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Pharmaceut Technol, PL-80416 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 199卷 / 01期

关键词：

isosorbide dinitrate; isosorbide mononitrate; percutaneous absorption; skin penetration enhancers;

D O I：

10.1016/S0378-5173(99)00363-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Percutaneous absorption of isosorbide dinitrate (ISDN) from a transdermal therapeutic system (TTS) with or without penetration enhancers was studied. The concentration of ISDN and its metabolites, isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN), was determined in rat plasma during a 48 h application of TTS. The increased skin-penetration enhancing: effect of oleic acid and propylene glycol in comparison to polyethylene glycol 400 and isopropyl myristate on percutaneous permeation of ISDN was shown. It was expressed by higher values of C-max and AUC. After the application of TTS, a lower ISDN and molar ratio of its metabolites was observed than after oral;administration. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 13 条

[1]

BABKO AK, 1955, ANAL KOLORYMETRYCZNA

[2]

DANJO K, 1994, CHEM PHARM BULL, V42, P2126

[3] BIOTRANSFORMATION OF ISOSORBIDE DINITRATE IN HUMANS [J].

DOWN, WH ;

CHASSEAUD, LF ;

GRUNDY, RK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1974, 63 (07) :1147-1149

[4] Hydrophilic polymeric matrices for enhanced transdermal drug delivery [J].

Feldstein, MM ;

Tohmakhchi, VN ;

Malkhazov, LB ;

Vasiliev, AE ;

Plate, NA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 131 (02) :229-242

[5] ENHANCED TRANSDERMAL DELIVERY OF ESTRADIOL IN-VITRO USING BINARY VEHICLES OF ISOPROPYL MYRISTATE AND SHORT-CHAIN ALKANOLS [J].

GOLDBERGCETTINA, M ;

LIU, PC ;

NIGHTINGALE, J ;

KURIHARABERGSTROM, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 114 (02) :237-245

[6] INFLUENCE OF ELECTRIC FOOT SHOCK ON PHARMACOKINETICS OF ISOSORBIDE DINITRATE ORALLY-ADMINISTERED TO RATS [J].

GOMITA, Y ;

FURUNO, K ;

ARAKI, Y .

JAPANESE JOURNAL OF PHARMACOLOGY, 1989, 49 (02) :297-299

[7]

KELLERSTANISLAWSKI B, 1992, ARZNEIMITTELFORSCH, V42-1, P17

[8] ABSORPTION OF ISOSORBIDE DINITRATE AFTER ADMINISTRATION AS SPRAY, OINTMENT AND MICROEMULSION PATCH - AN IN-VITRO STUDY USING THE ISOLATED-PERFUSED BOVINE UDDER [J].

KIETZMANN, M ;

WENZEL, B ;

LOSCHER, W ;

LUBACH, D ;

MULLER, BW ;

BLUME, H .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1995, 47 (01) :22-25

[9]

LAUFEN H, 1992, ARZNEIMITTEL-FORSCH, V42-2, P931

[10]

MENKE G, 1987, ARZNEIMITTEL-FORSCH, V37-2, P1301

← 1 2 →