Regulator of G-protein signaling (RGS) proteins in cancer biology

被引：133
作者：
Hurst, Jillian H. [1 ]
Hooks, Shelley B. [1 ]
机构：
[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
来源：
BIOCHEMICAL PHARMACOLOGY | 2009年 / 78卷 / 10期
关键词：
Regulator of G-protein signaling proteins; Cancer; G-protein coupled receptors; Signal transduction; GROWTH-FACTOR RECEPTOR; GENE-EXPRESSION PROFILES; MUTANT ALPHA-SUBUNIT; CELL LUNG-CANCER; BETA-CATENIN; PROSTATE-CANCER; LYSOPHOSPHATIDIC ACID; MESSENGER-RNA; COUPLED RECEPTORS; MUTATIONAL ANALYSES;
D O I：
10.1016/j.bcp.2009.06.028
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：1289 / 1297
页数：9
相关论文
共 50 条
  • [41] Expression of regulator of G-protein signaling protein-2 gene in the rat ovary at the time of ovulation
    Ujioka, T
    Russell, DL
    Okamura, H
    Richards, JS
    Espey, LL
    BIOLOGY OF REPRODUCTION, 2000, 63 (05) : 1513 - 1517
  • [42] Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function
    Osei-Owusu, Patrick
    Blumer, Kendall J.
    RGS PROTEIN PHYSIOLOGY AND PATHOPHYSIOLOGY, 2015, 133 : 77 - 92
  • [43] CXCL12 regulates platelet activation via the regulator of G-protein signaling 16
    Karim, Zubair A.
    Alshbool, Fatima Z.
    Vemana, Hari Priya
    Conlon, Christine
    Druey, Kirk M.
    Khasawneh, Fadi T.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2016, 1863 (02): : 314 - 321
  • [44] Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse
    Pacey, Laura K. K.
    Doss, Lilian
    Cifelli, Carlo
    van der Kooy, Derek
    Heximer, Scott P.
    Hampson, David R.
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2011, 46 (03) : 563 - 572
  • [45] Mechanism of miR-107-targeting of regulator of G-protein signaling 4 in hepatocellular carcinoma
    Xiao, Di
    Gao, Hai-Xia
    ONCOLOGY LETTERS, 2019, 18 (05) : 5145 - 5154
  • [46] Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8)
    Kobayashi, Yuki
    Takemoto, Risa
    Yamato, Shogo
    Okada, Tomoya
    Iijima, Michihiko
    Uematsu, Yoshikatsu
    Chaki, Shigeyuki
    Saito, Yumiko
    NEUROSCIENCE, 2018, 383 : 160 - 169
  • [47] IDENTIFICATION OF A RECEPTOR G-PROTEIN CONTACT SITE CRITICAL FOR SIGNALING SPECIFICITY AND G-PROTEIN ACTIVATION
    LIU, J
    CONKLIN, BR
    BLIN, N
    YUN, J
    WESS, J
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) : 11642 - 11646
  • [48] Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells
    Xu, Zumin
    Zuo, Yufang
    Wang, Jin
    Yu, Zhonghua
    Peng, Fang
    Chen, Yuanyuan
    Dong, Yong
    Hu, Xiao
    Zhou, Qichao
    Ma, Honglian
    Bao, Yong
    Chen, Ming
    ONCOLOGY REPORTS, 2015, 33 (06) : 2899 - 2907
  • [49] Regulators of G-Protein Signaling in the Heart and Their Potential as Therapeutic Targets
    Zhang, Peng
    Mende, Ulrike
    CIRCULATION RESEARCH, 2011, 109 (03) : 320 - 333
  • [50] Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis
    Feigin, Michael E.
    FEBS JOURNAL, 2013, 280 (19) : 4729 - 4738
12345