Naringenin Nano-Delivery Systems and Their Therapeutic Applications

被引：134

作者：

Bhia, Mohammed ^{[1
,2
]}

Motallebi, Mahzad ^{[3
]}

Abadi, Banafshe ^{[4
,5
]}

Zarepour, Atefeh ^{[6
]}

Pereira-Silva, Miguel ^{[7
,8
]}

Saremnejad, Farinaz ^{[9
]}

Santos, Ana Claudia ^{[7
,8
]}

Zarrabi, Ali ^{[10
,11
]}

Melero, Ana ^{[12
]}

Jafari, Seid Mandi ^{[13
]}

Shakibaei, Mehdi ^{[14
,15
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Pharm, Student Res Comm, Tehran 1996835113, Iran

[2] Universal Sci Educ & Res Network USERN, Nanomed Res Assoc NRA, Tehran 7616911319, Iran

[3] Islamic Azad Univ, Dept Biol, Yadegar E Imam Khomeini RAH Shahr E Rey Branch, Tehran 1815163111, Iran

[4] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, Kerman 7616911319, Iran

[5] Universal Sci Educ & Res Network USERN, Brain Canc Res Core BCRC, Tehran 1419733151, Iran

[6] Univ Isfahan, Fac Biol Sci & Technol, Dept Biotechnol, Esfahan 8174673441, Iran

[7] Univ Coimbra, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal

[8] Univ Coimbra, Fac Pharm, Grp Pharmaceut Technol, REQUIMTE LAQV, P-3000548 Coimbra, Portugal

[9] Ferdowsi Univ Mashhad, Dept Food Sci & Technol, Mashhad 9177948974, Razavi Khorasan, Iran

[10] Sabanci Univ Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[11] Sabanci Univ, Fac Engn & Nat Sci, Ctr Excellence Funct Surfaces & Interfaces EFSUN, TR-34956 Istanbul, Turkey

[12] Univ Valencia, Fac Pharm, Dept Pharm & Pharmaceut Technol & Parasitol, Avda Vincent Andres Estelles S-N, Burjassot 46100, Spain

[13] Gorgan Univ Agr Sci & Nat Resources, Dept Food Mat & Proc Design Engn, Gorgan 4918943464, Golestan, Iran

[14] Ludwig Maximilian Univ Munich, Fac Med, Inst Anat, Chair Vegetat Anat,Musculoskeletal Res Grp, D-80336 Munich, Germany

[15] Ludwig Maximilian Univ Munich, Fac Med, Inst Anat, Chair Vegetat Anat,Tumor Biol, D-80336 Munich, Germany

来源：

PHARMACEUTICS | 2021年 / 13卷 / 02期

关键词：

naringenin; nutraceuticals; antioxidants; natural products; nanoparticles; drug delivery; nanomedicine; bioavailability; flavonoid; LIPOSOMAL NANOFORMULATION PREPARATION; NANOSTRUCTURED LIPID CARRIERS; IN-VITRO; FLAVONOID NARINGENIN; DRUG-DELIVERY; TNF-ALPHA; POLYMERIC NANOPARTICLES; ANTIOXIDANT PROPERTIES; ORAL BIOAVAILABILITY; BETA-CYCLODEXTRIN;

D O I：

10.3390/pharmaceutics13020291

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nanoemulsions. These nanomedicine formulations of NRG have been applied as a potential treatment for several diseases, using a wide range of in vitro, ex vivo, and in vivo models and different routes of administration. From this review, it can be concluded that NRG is a potential therapeutic option for the treatment of various diseases such as cancer, neurological disorders, liver diseases, ocular disorders, inflammatory diseases, skin diseases, and diabetes when formulated in the appropriate nanocarriers.

引用

页码：1 / 29

页数：29

共 180 条

[1] Gelatin-Coated Polycaprolactone Nanoparticle-Mediated Naringenin Delivery Rescue Human Mesenchymal Stem Cells from Oxygen Glucose Deprivation-Induced Inflammatory Stress [J].