Not just angiotensinases: new roles for the angiotensin-converting enzymes

被引:66
作者
Lambert, Daniel W. [2 ]
Clarke, Nicola E. [1 ]
Turner, Anthony J. [1 ]
机构
[1] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England
[2] Univ Sheffield, Fac Med Dent & Hlth, Sheffield S10 2TA, S Yorkshire, England
基金
英国生物技术与生命科学研究理事会;
关键词
ACE; ACE2; Angiotensin; Signalling; Collectrin; SARS-CORONAVIRUS; BLOOD-PRESSURE; MESSENGER-RNA; ANGIOTENSIN-CONVERTING-ENZYME-2; ACE2; PULMONARY-HYPERTENSION; FUNCTIONAL RECEPTOR; HARTNUP DISORDER; PLASMA-MEMBRANE; GENE-EXPRESSION; TRANSGENIC MICE;
D O I
10.1007/s00018-009-0152-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. Angiotensin II, the primary bioactive peptide of the RAS, is generated from angiotensin I by angiotensin-converting enzyme (ACE). A homologue of ACE, ACE2, is able to convert angiotensin II to a peptide with opposing effects, angiotensin-(1-7). It is proposed that disturbance of the balance of ACE and ACE2 expression and/or function is important in pathologies in which angiotensin II plays a role. These include cardiovascular and renal disease, lung injury and liver fibrosis. The critical roles of ACE and ACE2 in regulating angiotensin II levels have traditionally focussed attention on their activities as angiotensinases. Recent discoveries, however, have illuminated the roles of these enzymes and of the ACE2 homologue, collectrin, in intracellular trafficking and signalling. This paper reviews the key literature regarding both the catalytic and non-catalytic roles of the angiotensin-converting enzyme gene family.
引用
收藏
页码:89 / 98
页数:10
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