Distinct but complementary contributions of PPAR isotypes to energy homeostasis

被引：310
作者：
Dubois, Vanessa [1 ,2 ]
Eeckhoute, Jerome [1 ,2 ]
Lefebvre, Philippe [1 ,2 ]
Staels, Bart [1 ,2 ]
机构：
[1] Univ Lille, CHU Lille, INSERM, Inst Pasteur Lille, U1011 EGID, Lille, France
[2] Inst Pasteur, 1 Rue Prof Calmette, F-59019 Lille, France
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2017年 / 127卷 / 04期
关键词：
PROLIFERATOR-ACTIVATED-RECEPTOR; CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; SINGLE NUCLEOTIDE POLYMORPHISMS; TYPE-2; DIABETES-MELLITUS; T-REG CELLS; DENSITY-LIPOPROTEIN-CHOLESTEROL; IMPROVES INSULIN SENSITIVITY; RANDOMIZED CONTROLLED-TRIAL; IMPAIRED GLUCOSE-TOLERANCE;
D O I：
10.1172/JCI88894
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Peroxisome proliferator-activated receptors (PPARs) regulate energy metabolism and hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. While they share anti-inflammatory activities, the PPAR isotypes distinguish themselves by differential actions on lipid and glucose homeostasis. In this Review we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the underlying cellular and molecular mechanisms, as well as the synthetic PPAR ligands that are used in the clinic or under development. We highlight the potential of new PPAR ligands with improved efficacy and safety profiles in the treatment of complex metabolic disorders.
引用
收藏
页码：1202 / 1214
页数：13
相关论文
共 193 条
[1]   PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors [J].
Akune, T ;
Ohba, S ;
Kamekura, S ;
Yamaguchi, M ;
Chung, UI ;
Kubota, N ;
Terauchi, Y ;
Harada, Y ;
Azuma, Y ;
Nakamura, K ;
Kadowaki, T ;
Kawaguchi, H .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (06) :846-855
[2]   Human Muscle Fiber Type-Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes [J].
Albers, Peter H. ;
Pedersen, Andreas J. T. ;
Birk, Jesper B. ;
Kristensen, Dorte E. ;
Vind, Birgitte F. ;
Baba, Otto ;
Nohr, Jane ;
Hojlund, Kurt ;
Wojtaszewski, Jorgen F. P. .
DIABETES, 2015, 64 (02) :485-497
[3]   Single nucleotide polymorphisms of the peroxisome proliferator-activated receptor-α gene (PPARA) influence the conversion from impaired glucose tolerance to type 2 diabetes -: The STOP-NIDDM trial [J].
Andrulionyte, Laura ;
Kuulasmaa, Teemu ;
Chiasson, Jean-Louis ;
Laakso, Markku .
DIABETES, 2007, 56 (04) :1181-1186
[4]   Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes -: The STOP-NIDDM trial [J].
Andrulionyte, Laura ;
Peltola, Paula ;
Chiasson, Jean-Louis ;
Laakso, Markku .
DIABETES, 2006, 55 (07) :2148-2152
[5]   Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells [J].
Angela, Mulki ;
Endo, Yusuke ;
Asou, Hikari K. ;
Yamamoto, Takeshi ;
Tumes, Damon J. ;
Tokuyama, Hirotake ;
Yokote, Koutaro ;
Nakayama, Toshinori .
NATURE COMMUNICATIONS, 2016, 7
[6]   An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ [J].
Banks, Alexander S. ;
McAllister, Fiona E. ;
Camporez, Joao Paulo G. ;
Zushin, Peter-James H. ;
Jurczak, Michael J. ;
Laznik-Bogoslavski, Dina ;
Shulman, Gerald I. ;
Gygi, Steven P. ;
Spiegelman, Bruce M. .
NATURE, 2015, 517 (7534) :391-U581
[7]   Depletion of fat-resident Treg cells prevents age-associated insulin resistance [J].
Bapat, Sagar P. ;
Suh, Jae Myoung ;
Fang, Sungsoon ;
Liu, Sihao ;
Zhang, Yang ;
Cheng, Albert ;
Zhou, Carmen ;
Liang, Yuqiong ;
LeBlanc, Mathias ;
Liddle, Christopher ;
Atkins, Annette R. ;
Yu, Ruth T. ;
Downes, Michael ;
Evans, Ronald M. ;
Zheng, Ye .
NATURE, 2015, 528 (7580) :137-+
[8]   PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation [J].
Barroso, Emma ;
Rodriguez-Rodriguez, Rosalia ;
Chacon, Matilde R. ;
Maymo-Masip, Elsa ;
Ferrer, Laura ;
Salvado, Laia ;
Salmeron, Emilio ;
Wabistch, Martin ;
Palomer, Xavier ;
Vendrell, Joan ;
Wahli, Walter ;
Vazquez-Carrera, Manuel .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (05) :1049-1058
[9]   The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation [J].
Barroso, Emma ;
Rodriguez-Calvo, Ricardo ;
Serrano-Marco, Lucia ;
Astudillo, Alma M. ;
Balsinde, Jesus ;
Palomer, Xavier ;
Vazquez-Carrera, Manuel .
ENDOCRINOLOGY, 2011, 152 (05) :1848-1859
[10]   Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension [J].
Barroso, I ;
Gurnell, M ;
Crowley, VEF ;
Agostini, M ;
Schwabe, JW ;
Soos, MA ;
Maslen, GL ;
Williams, TDM ;
Lewis, H ;
Schafer, AJ ;
Chatterjee, VKK ;
O'Rahilly, S .
NATURE, 1999, 402 (6764) :880-883
12345678910