Cutaneous side effects of hydroxyurea treatment for polycythemia vera

被引：9

作者：

Hoff, N. -P. ^{[1
]}

Akanay-Diesel, S. ^{[1
]}

Pippirs, U. ^{[1
]}

Schulte, K. -W. ^{[1
]}

Hanneken, S. ^{[1
]}

机构：

[1] Univ Klinikums Dusseldorf, Hautklin, D-40225 Dusseldorf, Germany

来源：

HAUTARZT | 2009年 / 60卷 / 10期

关键词：

Hydroxyurea treatment; Polycythemia vera; Cutaneous side effects;

D O I：

10.1007/s00105-009-1844-8

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A 68-year-old women with polycythemia vera was treated with hydroxyurea for 8 years and developed painful ulcers on her lower legs, multiple hypertrophic actinic keratoses and a squamous cell carcinoma. After discontinuing hydroxyurea therapy the leg ulcers resolved within 8 weeks. The hypertrophic actinic keratoses and squamous cell carcinoma were treated with cryotherapy and excision, respectively. Hydroxyurea induces a variety of cutaneous side effects such as painful leg ulcers and squamous cell carcinomas. Given the wide variety of adverse cutaneous side effects associated with long-term hydroxyurea therapy, the first step in management is to insure that physicians and patients are aware of the specific risks of this treatment. Patients under hydroxyurea therapy should be monitored closely by dermatologists to early detect and treat the cutaneous side effects.

引用

页码：783 / +

页数：4

共 9 条

[1] HYDROXYUREA THERAPY [J].

BOYD, AS .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1991, 25 (03) :518-524

[2]

De Simone C, 1998, EUR J DERMATOL, V8, P114

[3] Leg ulcer in a patient associated with hydroxyurea therapy [J].

Dissemond, J ;

Hoeft, D ;

Knab, J ;

Franckson, T ;

Kroger, K ;

Goos, M .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2006, 45 (02) :158-160

[4] INHIBITION OF DNA EXCISION REPAIR AND THE REPAIR OF X-RAY-INDUCED DNA DAMAGE BY CYTOSINE-ARABINOSIDE AND HYDROXYUREA [J].

FRAM, RJ ;

KUFE, DW .

PHARMACOLOGY & THERAPEUTICS, 1985, 31 (03) :165-176

[5]

GRANGE F, 1995, ANN DERMATOL VENER, V122, P16

[6] Hydroxyurea-associated squamous dysplasia [J].

Sanchez-Palacios, C ;

Guitart, J .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 51 (02) :293-300

[7] Myeloproliferative disorder therapy: assessment and management of adverse events-a dermatologist's perspective [J].

Soutou, Boutros ;

Aractingi, Selim .

HEMATOLOGICAL ONCOLOGY, 2009, 27 :11-13

[8] Leg ulcers associated with long-term hydroxyurea therapy [J].

Weinlich, G ;

Schuler, G ;

Greil, R ;

Kofler, H ;

Fritsch, P .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1998, 39 (02) :372-374

[9] The cutaneous side-effects of hydroxyurea [J].

Young, HS ;

Khan, ASA ;

Kendra, JR ;

Coulson, IH .

CLINICAL AND LABORATORY HAEMATOLOGY, 2000, 22 (04) :229-232

← 1 →