Photodynamic therapy: photosensitizers and nanostructures

被引：156

作者：

Escudero, Alberto ^{[1
,2
]}

Carrillo-Carrion, Carolina ^{[3
]}

Castillejos, Ma Carmen ^{[2
]}

Romero-Ben, Elena ^{[2
]}

Rosales-Barrios, Christian ^{[2
]}

Khiar, Noureddine ^{[2
]}

机构：

[1] Univ Seville, Fac Quim, Dept Quim Inorgan, Calle Prof Garcia Gonzalez 1, E-41012 Seville, Spain

[2] Univ Seville, CSIC, Inst Invest Quim IIQ, Ave Americo Vespucio 49, E-41092 Seville, Spain

[3] Univ Cordoba, Dept Quim Organ, Campus Rabanales,Edificio Marie Curie, E-14014 Cordoba, Spain

来源：

MATERIALS CHEMISTRY FRONTIERS | 2021年 / 5卷 / 10期

关键词：

METAL-ORGANIC FRAMEWORKS; AGGREGATION-INDUCED EMISSION; UP-CONVERSION NANOPARTICLES; SINGLET OXYGEN PRODUCTION; DRUG-DELIVERY; IN-VIVO; 5-AMINOLEVULINIC ACID; PROSTATE-CANCER; PHOTOTHERMAL THERAPY; POLYMERIC MICELLES;

D O I：

10.1039/d0qm00922a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactions of some structures to different external stimuli can be used for therapeutic purposes. In particular, in photodynamic therapy (PDT), a light-sensitive compound or structure, commonly named a photosensitizer (PS), is able to produce reactive oxygen species (ROS) after being irradiated with light in the presence of oxygen. Such ROS are effective in destroying cells and can be used as therapeutic agents to treat some skin and eye diseases, as well as certain types of cancer. This review will summarise the current state-of-the-art in PDT, with special focus on the different available photosensitizers, their chemistry, their incorporation into different nanostructures, and some of the current targeting strategies.

引用

页码：3788 / 3812

页数：25

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