Dissecting miRNA signature in colorectal cancer progression and metastasis

被引：67
作者：
Huang, Xiangjie [1 ]
Zhu, Xinping [1 ]
Yu, Yun [1 ]
Zhu, Wangyu [2 ]
Jin, Libo [3 ,4 ]
Zhang, Xiaodong [5 ]
Li, Shaotang [5 ]
Zou, Peng [1 ,3 ,4 ]
Xie, Congying [5 ]
Cui, Ri [1 ,3 ,4 ]
机构：
[1] Wenzhou Med Univ, Canc & Anticanc Drug Res Ctr, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Zhoushan Hosp, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
[3] Wenzhou Univ, Inst Life Sci, Wenzhou 325035, Zhejiang, Peoples R China
[4] Wenzhou Univ, Wenzhou Med Univ, Collaborat Innovat Ctr Biomed, Wenzhou 325035, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2021年 / 501卷
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; miRNA; miRNA dysregulation; Circulatory miRNAs; Drug resistance; PROMOTES TUMOR-GROWTH; CIRCULATING MICRORNAS; CELL-PROLIFERATION; DRUG-RESISTANCE; DOWN-REGULATION; POOR-PROGNOSIS; CETUXIMAB RESISTANCE; FEEDBACK LOOP; DIFFERENTIAL EXPRESSION; EPIGENETIC REGULATION;
D O I：
10.1016/j.canlet.2020.12.025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer related deaths worldwide. Despite recent advancements in surgical and molecular targeted therapies that improved the therapeutic efficacy in CRC, the 5 years survival rate of CRC patients still remains frustratingly poor. Accumulated evidences indicate that microRNAs (miRNAs) play a crucial role in the progression and metastasis of CRC. Dysregulated miRNAs are closely associated with cancerous phenotypes (e.g. enhanced proliferative and invasive ability, evasion of apoptosis, cell cycle aberration, and promotion of angiogenesis) by regulating their target genes. In this review, we provide an updated overview of tumor suppressive and oncogenic miRNAs, circulatory miRNAs, and the possible causes of dysregulated miRNAs in CRC. In addition, we discuss the important functions of miRNAs in drug resistance of CRC.
引用
收藏
页码：66 / 82
页数：17
相关论文
共 229 条
  • [1] MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA
    Al-Haidari, Amr A.
    Syk, Ingvar
    Thorlacius, Henrik
    [J]. ONCOTARGET, 2017, 8 (09) : 14887 - 14896
  • [2] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    Arroyo, Jason D.
    Chevillet, John R.
    Kroh, Evan M.
    Ruf, Ingrid K.
    Pritchard, Colin C.
    Gibson, Donald F.
    Mitchell, Patrick S.
    Bennett, Christopher F.
    Pogosova-Agadjanyan, Era L.
    Stirewalt, Derek L.
    Tait, Jonathan F.
    Tewari, Muneesh
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) : 5003 - 5008
  • [3] The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells
    Bai, Zhigang
    Wang, Jin
    Wang, Tingting
    Li, Yuan
    Zhao, Xiaomu
    Wu, Guocong
    Yang, Yingchi
    Deng, Wei
    Zhang, Zhongtao
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 44 (05) : 1882 - 1895
  • [4] Neurotensin Signaling Activates MicroRNAs-21 and-155 and Akt, Promotes Tumor Growth in Mice, and Is Increased in Human Colon Tumors
    Bakirtzi, Kyriaki
    Hatziapostolou, Maria
    Karagiannides, Iordanes
    Polytarchou, Christos
    Jaeger, Savina
    Iliopoulos, Dimitrios
    Pothoulakis, Charalabos
    [J]. GASTROENTEROLOGY, 2011, 141 (05) : 1749 - U311
  • [5] Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis
    Balaguer, Francesc
    Link, Alexander
    Lozano, Juan Jose
    Cuatrecasas, Miriam
    Nagasaka, Takeshi
    Boland, C. Richard
    Goel, Ajay
    [J]. CANCER RESEARCH, 2010, 70 (16) : 6609 - 6618
  • [6] Epigenetic regulation of microRNA expression in colorectal cancer
    Bandres, Eva
    Agirre, Xabier
    Bitarte, Nerea
    Ramirez, Natalia
    Zarate, Ruth
    Roman-Gomez, Jose
    Prosper, Felipe
    Garcia-Foncillas, Jesus
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (11) : 2737 - 2743
  • [7] MicroRNAs: Target Recognition and Regulatory Functions
    Bartel, David P.
    [J]. CELL, 2009, 136 (02) : 215 - 233
  • [8] Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer
    Basati, Gholam
    Razavi, Amirnader Emami
    Pakzad, Iraj
    Malayeri, Fardin Ali
    [J]. TUMOR BIOLOGY, 2016, 37 (02) : 1781 - 1788
  • [9] The Prognostic Value of MicroRNAs Varies with Patient Race/Ethnicity and Stage of Colorectal Cancer
    Bovell, Liselle C.
    Shanmugam, Chandrakumar
    Putcha, Balananda-Dhurjati K.
    Katkoori, Venkat R.
    Zhang, Bin
    Bae, Sejong
    Singh, Karan P.
    Grizzle, William E.
    Manne, Upender
    [J]. CLINICAL CANCER RESEARCH, 2013, 19 (14) : 3955 - 3965
  • [10] microRNA expression profile in stage III colorectal cancer: Circulating miR-18a and miR-29a as promising biomarkers
    Brunet Vega, Anna
    Pericay, Carles
    Moya, Irene
    Ferrer, Anna
    Dotor, Emma
    Pisa, Aleydis
    Casalots, Alex
    Serra-Aracil, Xavier
    Oliva, Joan-Carles
    Ruiz, Anna
    Saigi, Eugeni
    [J]. ONCOLOGY REPORTS, 2013, 30 (01) : 320 - 326
12345678910