Music exposure improves spatial cognition by enhancing the BDNF level of dorsal hippocampal subregions in the developing rats

被引：38

作者：

Xing, Yingshou ^{[1
,2
]}

Chen, Wenxi ^{[1
]}

Wang, Yanran ^{[1
]}

Jing, Wei ^{[1
]}

Gao, Shan ^{[1
]}

Guo, Daqing ^{[1
]}

Xia, Yang ^{[1
]}

Yao, Dezhong ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Med Informat Ctr, Key Lab NeuroInformat, Minist Educ, 4 Sect 2,North Jianshe Rd, Chengdu 610054, Peoples R China

[2] Yangtze Normal Univ, Sch Elect Informat Engn, Chongqing FuLing 408100, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2016年 / 121卷

基金：

中国国家自然科学基金;

关键词：

Hippocampal subregion; Mozart music; Cognitive ability; BDNF/TrkB; FACTOR MESSENGER-RNA; NEUROTROPHIC FACTOR; MEMORY; EXPRESSION; MAZE; MICE; NEUROGENESIS; LOCALIZATION; NEUROBIOLOGY; DISSOCIATION;

D O I：

10.1016/j.brainresbull.2016.01.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous research has shown that dorsal hippocampus plays an important role in spatial memory process. Music exposure can enhance brain-derived neurotrophic factor (BDNF) expression level in dorsal hippocampus (DH) and thus enhance spatial cognition ability. But whether music experience may affect different subregions of DH in the same degree remains unclear. Here, we studied the effects of exposure to Mozart K.448 on learning behavior in developing rats using the classical Morris water maze task. The results showed that early music exposure could enhance significantly learning performance of the rats in the water maze test. Meanwhile, the BDNF/TrkB level of dorsal hippocampus CA3 (dCA3) and dentate gyrus (dDG) was significantly enhanced in rats exposed to Mozart music as compared to those without music exposure. In contrast, the BDNF/TrkB level of dorsal hippocampus CA1 (dCA1) was not affected. The results suggest that the spatial memory improvement by music exposure in rats may be associated with the enhanced BDNF/TrkB level of dCA3 and dDG. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：131 / 137

页数：7

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