The optimal stimulation site for chronic stimulation of the subthalamic nucleus in Parkinson's disease

被引：24

作者：

Yokoyama, T ^{[1
]}

Sugiyama, K ^{[1
]}

Nishizawa, S ^{[1
]}

Yokota, N ^{[1
]}

Ohta, S ^{[1
]}

Akamine, S ^{[1
]}

Namba, H ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Neurosurg, Hamamatsu, Shizuoka 4313192, Japan

来源：

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | 2001年 / 77卷 / 1-4期

关键词：

Parkinson's disease; deep brain stimulation; subthalamic nucleus; stereotactic surgery;

D O I：

10.1159/000064598

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the optimal stimulation site within the subthalamic nucleus (STN), monopolar stimulation of four electrode contacts and the resulting effects on parkinsonian symptoms were evaluated in 10 consecutive patients. The UPDRS score for rigidity and akinesia improved significantly after stimulation at each of the contacts, compared to the pre-evaluation state (Fisher's test, p < 0.05). The most significant improvement was obtained after stimulation at contact-2 (rigidity: 74.4 +/- 20.4%, akinesia: 53.7 +/- 14.3%) (Fisher's test, p < 0.001). Contact-2 was located at the dorsal border of the STN at a mean distance of 0.3 +/- 0.7 mm. DBS at the dorsal border of the STN, where the stimulation affects the neurons as well as their axonal fibers, produces the greatest clinical improvement in parkinsonian symptoms. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：61 / 67

页数：7

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