Membrane lipids and transporter function

被引：47

作者：

Stieger, Bruno ^{[1
]}

Steiger, Julia ^{[1
]}

Locher, Kaspar P. ^{[2
]}

机构：

[1] Univ Zurich, Univ Hosp Zurich, Dept Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland

[2] Swiss Fed Inst Technol, Dept Biol, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2021年 / 1867卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

Transport protein; Lipids; Plasma membrane composition; Human lipid homeostasis; PHOTOSYNTHETIC REACTION-CENTER; MITOCHONDRIAL ADP/ATP CARRIER; P-GLYCOPROTEIN ACTIVITY; MULTIDRUG EFFLUX PUMP; VOLTAGE-GATED NA+; X-RAY-STRUCTURE; ABC TRANSPORTER; PROTEIN INTERACTIONS; CHOLESTEROL BINDING; STRUCTURAL BASIS;

D O I：

10.1016/j.bbadis.2021.166079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transport proteins are essential for cells in allowing the exchange of substances between cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids modulate the function of transmembrane proteins such as transporters in two ways: Lipids are tightly and specifically bound to transport proteins and in addition they modulate from the bulk of the lipid bilayer the function of transport proteins. This overview summarizes currently available information at the ultrastructural level on lipids tightly bound to transport proteins and the impact of altered bulk membrane lipid composition. Human diseases leading to altered lipid homeostasis will lead to altered membrane lipid composition, which in turn affect the function of transporter proteins.

引用

页数：11

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