Pharmacogenetics and cancer therapy

被引：178

作者：

Relling, MV

Dervieux, T

机构：

[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[2] Univ Tennessee, Coll Pharm, Memphis, TN 38163 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1038/35101056

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pharmacogenetics is the study of how genetic variations affect drug response. These variations can affect a patient's response to cancer drugs, for which there is usually a fine line between a dosage that has a therapeutic effect and one that produces toxicity. Gaining better insight into the genetic elements of both the patient and the tumour that affect drug efficacy will eventually allow for individualized dosage determination and fewer adverse effects.

引用

页码：99 / 108

页数：10

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