Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans

被引：65

作者：

Erlandsson, R ^{[1
]}

Wilson, JF ^{[1
]}

Pääbo, S ^{[1
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2000年 / 17卷 / 05期

关键词：

ZFY; ZFX; human sex chromosomes; Alu repeats; retroviral elements; retroviruslike elements;

D O I：

10.1093/oxfordjournals.molbev.a026359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We sequenced the genomic region containing the human Y-linked zinc finger gene (ZFY). Comparison of ZFY to the related region on the X chromosome (ZFX) and to autosomal sequences reveals a significant accumulation of transposable elements on the sex chromosomes. In addition, five times as many retroviruslike elements (RLEs) are present in the ZFY region as in the ZFX region. Thus, transposable elements accumulate more rapidly on the sex chromosomes, and the insertion of RLEs may occur more frequently in the male than in the female germ line. When the accumulation of substitutions in Alu elements was analyzed, it was found that the Alu elements at the Y-chromosomal locus diverged significantly faster than those at the X-chromosomal locus, whereas the divergence of autosomal Alu elements was intermediate. The male-to-female mutation rate ratio was estimated to be 2.5.

引用

页码：804 / 812

页数：9

共 49 条

[1] Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven [J].

Agulnik, AI ;

Bishop, CE ;

Lerner, JL ;

Agulnik, SI ;

Solovyev, VV .

MAMMALIAN GENOME, 1997, 8 (02) :134-138

[2] Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations [J].

Agulnik, AI ;

Zharkikh, A ;

Boettger-Tong, H ;

Bourgeron, T ;

McElreavey, K ;

Bishop, CE .

HUMAN MOLECULAR GENETICS, 1998, 7 (09) :1371-1377

[3] DNA variation in a 5-Mb region of the X chromosome and estimates of sex-specific/type-specific mutation rates [J].

Anagnostopoulos, T ;

Green, PM ;

Rowley, G ;

Lewis, CM ;

Giannelli, F .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (02) :508-517

[4] Standardized nomenclature for Alu repeats [J].

Batzer, MA ;

Deininger, PL ;

HellmannBlumberg, U ;

Jurka, J ;

Labuda, D ;

Rubin, CM ;

Schmid, CW ;

Zietkiewicz, E ;

Zuckerkandl, E .

JOURNAL OF MOLECULAR EVOLUTION, 1996, 42 (01) :3-6

[5]

Brown P. O., 1997, P161

[6]

Carroll RL., 1988, VERTEBRATE PALEONTOL

[7]

Chang BHJ, 1996, ZOOL STUD, V35, P36

[8] THE EVOLUTION OF SEX-CHROMOSOMES [J].

CHARLESWORTH, B .

SCIENCE, 1991, 251 (4997) :1030-1033

[9] THE EVOLUTIONARY DYNAMICS OF REPETITIVE DNA IN EUKARYOTES [J].

CHARLESWORTH, B ;

SNIEGOWSKI, P ;

STEPHAN, W .

NATURE, 1994, 371 (6494) :215-220

[10]

DEININGER PL, 1992, TRENDS GENET, V8, P307, DOI 10.1016/0168-9525(92)90262-3

← 1 2 3 4 5 →