Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis

Background Acne vulgaris, a chronic inflammatory dermatosis, affects approximately 85% of adolescents and young adults.The level of vitamin D in acne patients and the effect on acne patients of a vitamin D supplementation have previously been documented; however, it remains to be disputed whether vitamin D deficiency is normal in acne patients. Aims This paper explores the relationship between vitamin D and acne levels and the advantageous implications of vitamin D supplements on acne. Methods From every database start date until December 2020, we checked the PubMed, EMBASE, MEDLINE and the Cochrane libraries. Case-controls or randomized controlled trial reporting on the serum 25(OH)D level and the efficacy of vitamin D supplement to acne patients were included. Results The serum 25(OH)D levels in acne patients is lower (standardized mean difference = -7.66 ng/ml; 95% confidence interval (CI) = -10.92 to -4.40). Articles also revealed the prospect of a therapeutic breakthrough through the supplementing of vitamin D for acne patients. Conclusion Our research offers a new guide in the field of acne prevention and health care.