Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders

被引:72
作者
Paschon, Vera [1 ,3 ]
Takada, Silvia Honda [1 ]
Ikebara, Juliane Midori [1 ]
Sousa, Erica [1 ]
Raeisossadati, Reza [1 ]
Ulrich, Henning [2 ]
Kihara, Alexandre Hiroaki [1 ,3 ]
机构
[1] Univ Fed ABC, Ctr Matemat Computacao & Cognicao, Sao Bernardo Do Campo, SP, Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP, Brazil
[3] Univ Fed ABC, Lab Neurogenet, 112 Bloco Delta R Arcturus 3, BR-09606070 Sao Bernardo Do Campo, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Extracellular vesicles; EVs; Diseases; Parkinson's disease; Alzheimer's disease; ALS; Stroke; Long-distancecommunication; miRNAs; TLR ligands; TLR signalling; Neurodegeneration; Apoptosis; Central nervous system; CNS; AMYOTROPHIC-LATERAL-SCLEROSIS; ISCHEMIA-REPERFUSION INJURY; TRANSIENT FOCAL ISCHEMIA; NITRATED ALPHA-SYNUCLEIN; INNATE IMMUNE-RESPONSES; NF-KAPPA-B; ALZHEIMERS-DISEASE; EXTRACELLULAR VESICLES; CEREBRAL-ISCHEMIA; CELL ACTIVATION;
D O I
10.1007/s12035-015-9142-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, participate in intercellular communication, and particularly, in paracrine and endocrine signalling. The EVs and their specific contents have been considered hallmarks of different diseases. It has been recently discovered that EVs can co-transport nucleic acids such as DNAs, ribosomal RNAs, circular RNAs (circRNAs), long noncoding RNAs (lnRNAs) and microRNAs (miRNAs). miRNAs are important regulators of gene expression at the post-transcriptional level, although they may also play other roles. Recent evidence supports the hypothesis that miRNAs can activate Toll-like receptors (TLRs) under certain circumstances. TLRs belong to a multigene family of immune system receptors and have been recently described in the nervous system. In the immune system, TLRs are important for the recognition of the invading microorganisms, whereas in the nervous system, they recognise endogenous ligands released by undifferentiated or necrotic/injured cells. In the neuronal disease field, TLRs activity has been associated with amyotrophic lateral sclerosis (ALS), stroke, Alzheimer's and Parkinson's disease. Herein, we reviewed the current knowledge of the relationship between miRNA release by EVs and the inflammation signalling triggered by TLRs in neighbouring cells or during long-distance cell-to-cell communication. We highlight novel aspects of this communication mechanism, offering a valuable insight into such pathways in health and disease.
引用
收藏
页码:2016 / 2028
页数:13
相关论文
共 181 条
[1]   Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid [J].
Admyre, C ;
Grunewald, J ;
Thyberg, J ;
Gripenbäck, S ;
Tornling, G ;
Eklund, A ;
Scheynius, A ;
Gabrielsson, S .
EUROPEAN RESPIRATORY JOURNAL, 2003, 22 (04) :578-583
[2]   Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].
Arroyo, Jason D. ;
Chevillet, John R. ;
Kroh, Evan M. ;
Ruf, Ingrid K. ;
Pritchard, Colin C. ;
Gibson, Donald F. ;
Mitchell, Patrick S. ;
Bennett, Christopher F. ;
Pogosova-Agadjanyan, Era L. ;
Stirewalt, Derek L. ;
Tait, Jonathan F. ;
Tewari, Muneesh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008
[3]   TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY [J].
Arumugam, Thiruma V. ;
Okun, Eitan ;
Tang, Sung-Chun ;
Thundyil, John ;
Taylor, Stephen M. ;
Woodruff, Trent M. .
SHOCK, 2009, 32 (01) :4-16
[4]  
Askenase PW, 2014, BRAIN RES, VS0006-8993, P01343
[5]   Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia [J].
Barajon, Isabella ;
Serrao, Graziano ;
Arnaboldi, Francesca ;
Opizzi, Emanuela ;
Ripamonti, Gerlomina ;
Balsari, Andrea ;
Rumio, Cristiano .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2009, 57 (11) :1013-1023
[6]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
[7]   Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis [J].
Beers, David R. ;
Henkel, Jenny S. ;
Xiao, Qin ;
Zhao, Weihua ;
Wang, Jinghong ;
Yen, Albert A. ;
Siklos, Laszlo ;
McKercher, Scott R. ;
Appel, Stanley H. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (43) :16021-16026
[8]   Differential activation of Toll-like receptor-mediated apoptosis induced by hypoxia [J].
Ben Mkaddem, Sanae ;
Bens, Marcelle ;
Vandewalle, Alain .
ONCOTARGET, 2010, 1 (08) :741-750
[9]   Hepatic expression of toll-like receptors 3, 4, and 9 in primary biliary cirrhosis and chronic hepatitis C [J].
Benias, Petros C. ;
Gopal, Kavitha ;
Bodenheimer, Henry, Jr. ;
Theise, Neil D. .
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2012, 36 (05) :448-454
[10]   α-Synuclein alters toll-like receptor expression [J].
Beraud, Dawn ;
Twomey, Margaret ;
Bloom, Benjamin ;
Mittereder, Andrew ;
Ton, Vy ;
Neitzke, Katherine ;
Chasovskikh, Sergey ;
Mhyre, Timothy R. ;
Maguire-Zeiss, Kathleen A. .
FRONTIERS IN NEUROSCIENCE, 2011, 5