The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

被引：522

作者：

Pomerantz, Mark M. ^{[1
]}

Ahmadiyeh, Nasim ^{[1
,2
]}

Jia, Li ^{[3
]}

Herman, Paula ^{[1
]}

Verzi, Michael P. ^{[1
]}

Doddapaneni, Harshavardhan ^{[4
]}

Beckwith, Christine A. ^{[1
]}

Chan, Jennifer A. ^{[5
]}

Hills, Adam ^{[1
]}

Davis, Matt ^{[1
]}

Yao, Keluo ^{[1
]}

Kehoe, Sarah M. ^{[1
]}

Lenz, Heinz-Josef ^{[6
]}

Haiman, Christopher A. ^{[6
]}

Yan, Chunli ^{[3
]}

Henderson, Brian E. ^{[6
]}

Frenkel, Baruch ^{[7
]}

Barretina, Jordi ^{[1
]}

Bass, Adam ^{[1
]}

Tabernero, Josep ^{[8
]}

Baselga, Jose ^{[8
]}

Regan, Meredith M. ^{[9
]}

Manak, J. Robert ^{[4
]}

Shivdasani, Ramesh ^{[1
]}

Coetzee, Gerhard A. ^{[3
]}

Freedman, Matthew L. ^{[1
,10
,11
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA

[3] USC, Keck Sch Med, Dept Urol, Los Angeles, CA USA

[4] Univ Iowa, Dept Biol, Iowa City, IA 52242 USA

[5] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 1N4, Canada

[6] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[7] Univ So Calif, Keck Sch Med, Inst Med Genet, Los Angeles, CA 90033 USA

[8] Vall Hebron Univ Hosp, Vall Hebron Inst Oncol, Catalonia, Spain

[9] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA

[10] Broad Inst Harvard, Cambridge, MA USA

[11] MIT, Cambridge, MA 02139 USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 08期

基金：

美国国家卫生研究院;

关键词：

WIDE ASSOCIATION SCAN; CHROMOSOME; 8Q24; BETA-CATENIN; GENOME; ACTIVATION; ENHANCERS; PROSTATE; APC;

D O I：

10.1038/ng.403

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC protooncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.

引用

页码：882 / 884

页数：3

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