Accumulation of arsenic in tissues of iron-deficient rats

被引：21
|
作者：
Paul, PC [1 ]
Misbahuddin, M [1 ]
Ahmed, ANN [1 ]
Dewan, ZF [1 ]
Mannan, MA [1 ]
机构：
[1] Bangabandhu Sheikh Mujib Med Univ, Dept Pharmacol, Dhaka, Bangladesh
来源：
TOXICOLOGY LETTERS | 2002年 / 135卷 / 03期
关键词：
arsenic; ferrireductase; iron deficiency; rats;
D O I：
10.1016/S0378-4274(02)00278-3
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Toxic concentration of arsenic (400 mug/kg body weight/day) was administered orally for 8 weeks to both iron-supplemented and iron-deficient rats. The results showed greater amount of arsenic in both the duodenum and liver of iron-deficient rats, compared to iron-supplemented ones. Duodenum containing high concentration of arsenic in iron-deficient rats showed significant reduction of ferrireductase (the enzyme responsible for the conversion of ferric iron to ferrous one) activity. Our results suggest that anemic rats are more prone to develop arsenic poisoning following chronic ingestion of high content of arsenic. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：193 / 197
页数：5
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