Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial

被引：17

作者：

Ruoss, J. Lauren ^{[1
]}

Bazacliu, Catalina ^{[1
]}

Russell, Jordan T. ^{[2
]}

de la Cruz, Diomel ^{[1
]}

Li, Nan ^{[1
]}

Gurka, Matthew J. ^{[3
]}

Filipp, Stephanie L. ^{[3
]}

Polin, Richard A. ^{[4
]}

Triplett, Eric W. ^{[2
]}

Neu, Josef ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Pediat, Div Neonatol, Gainesville, FL USA

[2] Univ Florida, Coll Med, Dept Microbiol & Cell Sci, Inst Food & Agr Sci, Gainesville, FL USA

[3] Univ Florida, Coll Med, Dept Hlth Outcomes & Biomed Informat, Gainesville, FL USA

[4] Columbia Univ, Dept Pediat, Coll Phys & Surg, New York, NY 10027 USA

来源：

JOURNAL OF PEDIATRICS | 2021年 / 229卷

基金：

美国国家卫生研究院;

关键词：

INTENSIVE-CARE-UNIT; EARLY-ONSET SEPSIS; NECROTIZING ENTEROCOLITIS; MICROBIOME; BACTERIAL; INFANTS; DEATH; RISK; NEC; GUT;

D O I：

10.1016/j.jpeds.2020.09.056

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.

引用

页码：294 / +

页数：8

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