Synthesis and in vitro antitumoral activity of new N-phenyl-3-pyrrolecarbothioamides

被引：35

作者：

Cocco, MT ^{[1
]}

Congiu, C ^{[1
]}

Onnis, V ^{[1
]}

机构：

[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(02)00465-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of N-phenylpyrrolecarbothioamides were obtained from base catalyzed intramolecular cyclization of 3-amino-3-(alkyl or arylamino)propenethioamides. Pyrrole derivatives were evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancer. Some of newly prepared compounds demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-6) M level and in some case at 10(-8) M concentrations. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：495 / 503

页数：9

共 25 条

[1] Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents [J].

Almerico, AM ;

Mingoia, F ;

Diana, P ;

Barraja, P ;

Montalbano, A ;

Lauria, A ;

Loddo, R ;

Sanna, L ;

Delpiano, D ;

Setzu, MG ;

Musiu, C .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (01) :3-10

[2] CHARACTERIZATION OF THE ANTIVIRAL ACTIVITY OF HIGHLY SUBSTITUTED PYRROLES - A NOVEL CLASS OF NONNUCLEOSIDE HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR [J].

ANTONUCCI, T ;

WARMUS, JS ;

HODGES, JC ;

NICKELL, DG .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1995, 6 (02) :98-108

[3] STRUCTURE + SYNTHESIS OF DISTAMYCIN A [J].

ARCAMONE, F ;

NICOLELL.V ;

PENCO, S ;

OREZZI, P ;

PIRELLI, A .

NATURE, 1964, 203 (494) :1064-+

[4]

Arcamone F, 1967, GAZZ CHIM ITAL, V97, P1097

[5]

ARTICO M, 1994, MED CHEM RES, V4, P283

[6]

Boyd M. R., 1989, CANCER PRINCIPLES PR, V3, P1

[7] SOME PRACTICAL CONSIDERATIONS AND APPLICATIONS OF THE NATIONAL-CANCER-INSTITUTE IN-VITRO ANTICANCER DRUG DISCOVERY SCREEN [J].

BOYD, MR ;

PAULI, KD .

DRUG DEVELOPMENT RESEARCH, 1995, 34 (02) :91-109

[8] Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: Novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity [J].

Campiani, G ;

Nacci, V ;

Fiorini, I ;

DeFilippis, MP ;

Garofalo, A ;

Greco, G ;

Novellino, E ;

Altamura, S ;

DiRenzo, L .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (14) :2672-2680

[9] Synthesis and in vitro cytotoxic activity of pyrrolo[2,3-e]indole derivatives and a dihydro benzoindole analogue [J].

Chacón-García, L ;

Martínez, R .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (03) :261-266

[10]

Cirrincione G, 1996, FARMACO, V51, P275

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