Application of CRISPR/Cas9 System to Reverse ABC-Mediated Multidrug Resistance

被引：6

作者：

Wang, Wei ^{[1
]}

Liang, Ze ^{[1
]}

Ma, Pengfei ^{[1
]}

Zhao, Qi ^{[2
]}

Dai, Mengyuan ^{[3
]}

Zhu, Jie ^{[3
]}

Han, Xu ^{[1
]}

Xu, Hong ^{[4
]}

Chang, Qingyan ^{[5
]}

Zhen, Yuhong ^{[1
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 1, Dalian 116023, Peoples R China

[3] Dalian Med Univ, Affiliated Hosp 2, Dalian 116011, Peoples R China

[4] Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R China

[5] Dalian Med Univ, Pharm Dept, Dalian People Hosp 6, Dalian 116031, Peoples R China

来源：

BIOCONJUGATE CHEMISTRY | 2021年 / 32卷 / 01期

关键词：

EPITHELIAL OVARIAN-CANCER; P-GLYCOPROTEIN; IN-VIVO; EFFLUX TRANSPORTERS; CRISPR-CAS9; SYSTEM; DELIVERY; CELLS; RNA; PROTEIN; MDR1;

D O I：

10.1021/acs.bioconjchem.0c00627

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Multidrug resistance (MDR) is the main obstacle in cancer chemotherapy. ATP-binding cassette (ABC) transporters Drugs can transport a wide range of antitumor drugs out of cells, which is the most common reason in the development of resistance to drugs. Currently, various therapeutic strategies are used to reverse MDR, among which CRISPR/Cas9 gene editing technique is expected to be an effective way. Here, we reviewed the research progress of reversing ABC-mediated drug resistance by CRISPR/Cas9 system.

引用

页码：73 / 81

页数：9

共 79 条

[1] ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: what is the way forward? [J].

Adamska, Aleksandra ;

Falasca, Marco .

WORLD JOURNAL OF GASTROENTEROLOGY, 2018, 24 (29) :3222-3238

[2] Perspectives, issues and solutions in RNAi therapy: the expected and the less expected [J].

Aigner, Achim .

NANOMEDICINE, 2019, 14 (21) :2777-2782

[3] Tyrosine Kinase Inhibitors as Reversal Agents for ABC Transporter Mediated Drug Resistance [J].

Anreddy, Nagaraju ;

Gupta, Pranav ;

Kathawala, Rishil J. ;

Patel, Atish ;

Wurpel, John N. D. ;

Chen, Zhe-Sheng .

MOLECULES, 2014, 19 (09) :13848-13877

[4] ATP-binding cassette transmembrane transporters and their epigenetic control in cancer: an overview [J].

Arrigoni, Elena ;

Galimberti, Sara ;

Petrini, Mario ;

Danesi, Romano ;

Di Paolo, Antonello .

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2016, 12 (12) :1419-1432

[5] ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance [J].

Begicevic, Romana-Rea ;

Falasca, Marco .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (11)

[6] Structural basis for the mechanism of ABC transporters [J].

Beis, Konstantinos .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2015, 43 :889-893

[7] Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma [J].

Besse, A. ;

Stolze, S. C. ;

Rasche, L. ;

Weinhold, N. ;

Morgan, G. J. ;

Kraus, M. ;

Bader, J. ;

Overkleeft, H. S. ;

Besse, L. ;

Driessen, C. .

LEUKEMIA, 2018, 32 (02) :391-401

[8] The therapeutic potential of targeting ABC transporters to combat multi-drug resistance [J].

Bugde, Piyush ;

Biswas, Riya ;

Merien, Fabrice ;

Lu, Jun ;

Liu, Dong-Xu ;

Chen, Mingwei ;

Zhou, Shufeng ;

Li, Yan .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2017, 21 (05) :511-530

[9] SnapShot: CRISPR-RNA-Guided Adaptive Immune Systems [J].

Carter, Joshua ;

Wiedenheft, Blake .

CELL, 2015, 163 (01) :260-U284

[10] Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer [J].

Chen, Yinnan ;

Zhang, Yanmin .

ADVANCED SCIENCE, 2018, 5 (06)

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