Different Applications of Virus-Like Particles in Biology and Medicine: Vaccination and Delivery Systems

被引：108
作者：
Shirbaghaee, Zeinab [1 ,2 ,3 ]
Bolhassani, Azam [1 ,2 ]
机构：
[1] Pasteur Inst Iran, Dept Hepatitis, Tehran, Iran
[2] Pasteur Inst Iran, AIDS, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
来源：
BIOPOLYMERS | 2016年 / 105卷 / 03期
基金：
美国国家科学基金会;
关键词：
virus-like particles; prokaryotic and eukaryotic systems; vaccination; delivery system; clinical trials; HEPATITIS-B-VACCINE; ROUS-SARCOMA-VIRUS; RECOMBINANT PROTEIN THERAPEUTICS; SUPRAMOLECULAR BUILDING-BLOCKS; PAPILLOMAVIRUS-LIKE PARTICLES; NUCLEOCAPSID-LIKE PARTICLES; HUMAN IMMUNE-RESPONSES; DENDRITIC CELLS; NEUTRALIZING ANTIBODIES; SURFACE-ANTIGEN;
D O I：
10.1002/bip.22759
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Virus-like particles (VLPs) mimic the whole construct of virus particles devoid of viral genome as used in subunit vaccine design. VLPs can elicit efficient protective immunity as direct immunogens compared to soluble antigens co-administered with adjuvants in several booster injections. Up to now, several prokaryotic and eukaryotic systems such as insect, yeast, plant, and E. coli were used to express recombinant proteins, especially for VLP production. Recent studies are also generating VLPs in plants using different transient expression vectors for edible vaccines. VLPs and viral particles have been applied for different functions such as gene therapy, vaccination, nanotechnology, and diagnostics. Herein, we describe VLP production in different systems as well as its applications in biology and medicine. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码：113 / 132
页数：20
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