A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries

被引：31

作者：

Rothwell, Joseph A. ^{[1
]}

Keski-Rahkonen, Pekka ^{[1
]}

Robinot, Nivonirina ^{[1
]}

Assi, Nada ^{[1
]}

Casagrande, Corinne ^{[1
]}

Jenab, Mazda ^{[1
]}

Ferrari, Pietro ^{[1
]}

Boutron-Ruault, Marie-Christine ^{[2
,3
]}

Mahamat-Saleh, Yahya ^{[2
,3
]}

Mancini, Francesca Romana ^{[2
,3
]}

Boeing, Heiner ^{[4
]}

Katzke, Verena ^{[5
]}

Kuehn, Tilman ^{[5
]}

Niforou, Katerina ^{[6
]}

Trichopoulou, Antonia ^{[6
]}

Valanou, Elisavet ^{[6
,7
]}

Krogh, Vittorio ^{[8
]}

Mattiello, Amalia ^{[9
]}

Palli, Domenico ^{[10
]}

Sacerdote, Carlotta ^{[11
,12
]}

Tumino, Rosario ^{[13
]}

Scalbert, Augustin ^{[1
]}

机构：

[1] IARC, Nutr & Metab Sect, 150 Cours Albert Thomas, F-69372 Lyon, France

[2] Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, French Natl Inst Hlth & Med Res INSERM, UVSQ,Univ Paris Saclay, F-94805 Villejuif, France

[3] Inst Gustave Roussy, F-94805 Villejuif, France

[4] German Inst Human Nutr Potsdam Rehbrucke, D-14558 Nuthetal, Germany

[5] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[6] Hellenic Hlth Fdn, Athens 11527, Greece

[7] Univ Athens, ATTIKON Univ, Sch Med, Pulm Med Dept, Athens, Greece

[8] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, I-20133 Milan, Italy

[9] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy

[10] Canc Res & Prevent Inst ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, I-50139 Florence, Italy

[11] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[12] Ctr Canc Prevent CPO, Turin, Italy

[13] Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, Prov Hlth Unit, Ragusa, Italy

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2019年 / 63卷 / 22期

关键词：

coffee; dietary biomarkers; diketopiperazines; metabolomics; trigonelline; 24-HOUR DIET RECALL; CONSUMPTION; CANCER; IDENTIFICATION; DIKETOPIPERAZINES; ASSOCIATION; BIOACTIVES; MORTALITY; CAFFEINE; URINE;

D O I：

10.1002/mnfr.201900659

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Scope The goal of this work is to identify circulating biomarkers of habitual coffee intake using a metabolomic approach, and to investigate their associations with coffee intake in four European countries. Methods and results Untargeted mass spectrometry-based metabolic profiling is performed on serum samples from 451 participants of the European Prospective Investigation on Cancer and Nutrition (EPIC) originating from France, Germany, Greece, and Italy. Eleven coffee metabolites are found to be associated with self-reported habitual coffee intake, including eight more strongly correlated (r = 0.25-0.51, p < 10E(-07)). Trigonelline shows the highest correlation, followed by caffeine, two caffeine metabolites (paraxanthine and 5-Acetylamino-6-amino-3-methyluracil), quinic acid, and three compounds derived from coffee roasting (cyclo(prolyl-valyl), cyclo(isoleucyl-prolyl), cyclo(leucyl-prolyl), and pyrocatechol sulfate). Differences in the magnitude of correlations are observed between countries, with trigonelline most highly correlated with coffee intake in France and Germany, quinic acid in Greece, and cyclo(isoleucyl-prolyl) in Italy. Conclusion Several biomarkers of habitual coffee intake are identified. No unique biomarker is found to be optimal for all tested populations. Instead, optimal biomarkers are shown to depend on the population and on the type of coffee consumed. These biomarkers should help to further explore the role of coffee in disease risk.

引用

页数：10

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